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Cystatin B (CSTB)
Cystatin B (CSTB)
Cys-B; CST6; EPM1; PME; STFB; CPI-B; Stefin B; Liver thiol proteinase inhibitor
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens.
CysB encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
O424Hu01
Recombinant Cystatin B (CSTB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cystatin B (CSTB) Bioactivity
Antibodies
MO424Hu21
Monoclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IP.
PO424Hu01
Polyclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cystatin B (CSTB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cystatin B (CSTB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cystatin B (CSTB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry;ICC/IF
Assay Kits
KEO424Hu
ELISA Kit for Cystatin B (CSTB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cystatin B (CSTB) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
O424Mu01
Recombinant Cystatin B (CSTB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cystatin B (CSTB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IP.
PO424Mu01
Polyclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IF.
LO424Mu71
Biotin Linked-Polyclonal Antibody to Cystatin B (CSTB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cystatin B (CSTB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cystatin B (CSTB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cystatin B (CSTB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cystatin B (CSTB) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
O424Ra01
Recombinant Cystatin B (CSTB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cystatin B (CSTB) Bioactivity
Antibodies
MO424Ra21
Monoclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IP.
PO424Ra01
Polyclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IF.
LO424Ra74
Biotin Linked-Polyclonal Antibody to Cystatin B (CSTB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cystatin B (CSTB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cystatin B (CSTB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cystatin B (CSTB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cystatin B (CSTB) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cystatin B (CSTB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cystatin B (CSTB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cystatin B (CSTB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cystatin B (CSTB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cystatin B (CSTB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cystatin B (CSTB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cystatin B (CSTB) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cystatin B (CSTB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cystatin B (CSTB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cystatin B (CSTB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cystatin B (CSTB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cystatin B (CSTB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cystatin B (CSTB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cystatin B (CSTB) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
O424Bo01
Recombinant Cystatin B (CSTB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cystatin B (CSTB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IP.
PO424Bo01
Polyclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IF.
LO424Bo71
Biotin Linked-Polyclonal Antibody to Cystatin B (CSTB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cystatin B (CSTB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cystatin B (CSTB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cystatin B (CSTB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cystatin B (CSTB) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cystatin B (CSTB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cystatin B (CSTB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cystatin B (CSTB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cystatin B (CSTB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cystatin B (CSTB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cystatin B (CSTB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cystatin B (CSTB) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cystatin B (CSTB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cystatin B (CSTB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cystatin B (CSTB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cystatin B (CSTB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cystatin B (CSTB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cystatin B (CSTB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cystatin B (CSTB) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cystatin B (CSTB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cystatin B (CSTB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cystatin B (CSTB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cystatin B (CSTB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cystatin B (CSTB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cystatin B (CSTB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cystatin B (CSTB) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cystatin B (CSTB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cystatin B (CSTB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cystatin B (CSTB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cystatin B (CSTB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cystatin B (CSTB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cystatin B (CSTB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cystatin B (CSTB) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cystatin B (CSTB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cystatin B (CSTB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cystatin B (CSTB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cystatin B (CSTB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cystatin B (CSTB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cystatin B (CSTB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cystatin B (CSTB) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cystatin B (CSTB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cystatin B (CSTB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cystatin B (CSTB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cystatin B (CSTB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cystatin B (CSTB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cystatin B (CSTB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cystatin B (CSTB) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cystatin B (CSTB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cystatin B (CSTB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cystatin B (CSTB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cystatin B (CSTB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cystatin B (CSTB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cystatin B (CSTB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cystatin B (CSTB) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cystatin B (CSTB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cystatin B (CSTB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cystatin B (CSTB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cystatin B (CSTB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cystatin B (CSTB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cystatin B (CSTB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cystatin B (CSTB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cystatin B (CSTB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cystatin B (CSTB) CLIA assay for Antigen Detection
Reference
"Amino acid sequence of the intracellular cysteine proteinase inhibitor cystatin B from human liver." Biochem. Biophys. Res. Commun. 131:1187-1192(1985) [PubMed ] [Europe PMC ] [Abstract ]
"Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1)." Science 271:1731-1734(1996) [PubMed ] [Europe PMC ] [Abstract ]
"The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed ] [Europe PMC ] [Abstract ]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14:2121-2127(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Nuclear localization of cystatin B, the cathepsin inhibitor implicated in myoclonus epilepsy (EPM1)." Exp. Cell Res. 262:84-94(2001) [PubMed ] [Europe PMC ] [Abstract ]
"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Anal. Chem. 81:4493-4501(2009) [PubMed ] [Europe PMC ] [Abstract ]
"Initial characterization of the human central proteome." BMC Syst. Biol. 5:17-17(2011) [PubMed ] [Europe PMC ] [Abstract ]
"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features." Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed ] [Europe PMC ] [Abstract ]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome." J. Proteomics 96:253-262(2014) [PubMed ] [Europe PMC ] [Abstract ]
"The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction." PubMed ] [Europe PMC ] [Abstract ]
"Identification of mutations in cystatin B, the gene responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy (EPM1)." PubMed ] [Europe PMC ] [Abstract ]
