Cystatin 4 (CST4)
Cystatin S; Salivary acidic protein 1; Cystatin-SA-III
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions.
CST4 is located in the cystatin locus and encodes a type 2 salivary cysteine peptidase inhibitor. The protein is an S-type cystatin, based on its high level of expression in saliva, tears and seminal plasma. The specific role in these fluids is unclear but antibacterial and antiviral activity is present, consistent with a protective function.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | O422Hu01 | Recombinant Cystatin 4 (CST4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cystatin 4 (CST4) | Bioactivity | |
| Antibodies | MO422Hu21 | Monoclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IP. |
| PO422Hu01 | Polyclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IF. | |
| LO422Hu71 | Biotin Linked-Polyclonal Antibody to Cystatin 4 (CST4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEO422Hu | ELISA Kit for Cystatin 4 (CST4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cystatin 4 (CST4) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cystatin 4 (CST4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cystatin 4 (CST4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cystatin 4 (CST4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cystatin 4 (CST4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cystatin 4 (CST4) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cystatin 4 (CST4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cystatin 4 (CST4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cystatin 4 (CST4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cystatin 4 (CST4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cystatin 4 (CST4) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cystatin 4 (CST4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cystatin 4 (CST4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cystatin 4 (CST4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cystatin 4 (CST4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cystatin 4 (CST4) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cystatin 4 (CST4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cystatin 4 (CST4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cystatin 4 (CST4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cystatin 4 (CST4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cystatin 4 (CST4) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cystatin 4 (CST4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cystatin 4 (CST4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cystatin 4 (CST4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cystatin 4 (CST4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cystatin 4 (CST4) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cystatin 4 (CST4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cystatin 4 (CST4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cystatin 4 (CST4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cystatin 4 (CST4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cystatin 4 (CST4) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cystatin 4 (CST4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cystatin 4 (CST4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cystatin 4 (CST4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cystatin 4 (CST4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cystatin 4 (CST4) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cystatin 4 (CST4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cystatin 4 (CST4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cystatin 4 (CST4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cystatin 4 (CST4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cystatin 4 (CST4) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cystatin 4 (CST4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cystatin 4 (CST4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cystatin 4 (CST4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cystatin 4 (CST4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cystatin 4 (CST4) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cystatin 4 (CST4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cystatin 4 (CST4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cystatin 4 (CST4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cystatin 4 (CST4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cystatin 4 (CST4) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cystatin 4 (CST4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cystatin 4 (CST4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cystatin 4 (CST4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cystatin 4 (CST4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cystatin 4 (CST4) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cystatin 4 (CST4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cystatin 4 (CST4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cystatin 4 (CST4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cystatin 4 (CST4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cystatin 4 (CST4) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cystatin 4 (CST4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cystatin 4 (CST4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cystatin 4 (CST4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cystatin 4 (CST4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cystatin 4 (CST4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cystatin 4 (CST4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cystatin 4 (CST4) | CLIA assay for Antigen Detection |
Reference
"Human salivary cystatin S. Cloning, sequence analysis, hybridization in situ and immunocytochemistry."
Biochem. J. 278:627-635(1991) [PubMed] [Europe PMC] [Abstract]
"Characterization of two members (CST4 and CST5) of the cystatin gene family and molecular evolution of cystatin genes."
Agents Actions 38:340-348(1992) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of a long form of cystatin from human saliva by rapid microbore HPLC mapping."
Biochem. Biophys. Res. Commun. 145:1248-1253(1987) [PubMed] [Europe PMC] [Abstract]
"Large-scale purification and characterization of the major phosphoproteins and mucins of human submandibular-sublingual saliva."
Biochem. J. 280:341-352(1991) [PubMed] [Europe PMC] [Abstract]
"Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S."
J. Biochem. 110:648-654(1991) [PubMed] [Europe PMC] [Abstract]
"The effects of human salivary cystatins and statherin on hydroxyapatite crystallization."
Arch. Oral Biol. 36:631-636(1991) [PubMed] [Europe PMC] [Abstract]
"Isolation and amino acid sequence of SAP-1, an acidic protein of human whole saliva, and sequence homology with human gamma-trace."
J. Biochem. 96:489-498(1984) [PubMed] [Europe PMC] [Abstract]
"Cystatin S: a cysteine proteinase inhibitor of human saliva."
J. Biochem. 96:1311-1314(1984) [PubMed] [Europe PMC] [Abstract]
"Salivary cystatin SA-III, a potential precursor of the acquired enamel pellicle, is phosphorylated at both its amino- and carboxyl-terminal regions."
Arch. Biochem. Biophys. 288:664-670(1991) [PubMed] [Europe PMC] [Abstract]
"Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry."
J. Am. Soc. Mass Spectrom. 21:908-917(2010) [PubMed] [Europe PMC] [Abstract]
"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]