Cartilage Associated Protein (CRTAP)

CASP; LEPREL3; Leprecan-Like 3

SPN	O409
HGNC	2379
MGI	1891221
PubMed	18566967
RGD	1565180
UniProt	O75718
Wiki	CRTAP

CRTAP is similar to the chicken and mouse CRTAP genes. The encoded protein is a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli.

Crtap is highly expressed in mouse growth plate proliferating chondrocytes and in cells at the chondroosseous junction. At embryonic day 15.5, it is expressed strongly in the presumptive bone collar of the diaphyses, where vascular and osteoblast invasion is initiated. Its expression is low in hypertrophic chondrocytes, and RT-PCR analysis confirmed expression in both osteoclasts and osteoblasts. Most of the Crtap protein is located within cells, although some signal was detected in the extracellular matrix.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	O409Hu01	Recombinant Cartilage Associated Protein (CRTAP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cartilage Associated Protein (CRTAP)	Bioactivity
Antibodies	MO409Hu21	Monoclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IP.
	PO409Hu01	Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry;ICC/IF
Assay Kits	KEO409Hu	ELISA Kit for Cartilage Associated Protein (CRTAP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cartilage Associated Protein (CRTAP)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	O409Mu01	Recombinant Cartilage Associated Protein (CRTAP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cartilage Associated Protein (CRTAP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IP.
	PO409Mu01	Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry;ICC/IF
Assay Kits	KEO409Mu	ELISA Kit for Cartilage Associated Protein (CRTAP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cartilage Associated Protein (CRTAP)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cartilage Associated Protein (CRTAP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cartilage Associated Protein (CRTAP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cartilage Associated Protein (CRTAP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cartilage Associated Protein (CRTAP)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cartilage Associated Protein (CRTAP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cartilage Associated Protein (CRTAP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cartilage Associated Protein (CRTAP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cartilage Associated Protein (CRTAP)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cartilage Associated Protein (CRTAP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cartilage Associated Protein (CRTAP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cartilage Associated Protein (CRTAP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cartilage Associated Protein (CRTAP)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cartilage Associated Protein (CRTAP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cartilage Associated Protein (CRTAP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cartilage Associated Protein (CRTAP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cartilage Associated Protein (CRTAP)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cartilage Associated Protein (CRTAP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cartilage Associated Protein (CRTAP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cartilage Associated Protein (CRTAP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cartilage Associated Protein (CRTAP)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cartilage Associated Protein (CRTAP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cartilage Associated Protein (CRTAP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cartilage Associated Protein (CRTAP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cartilage Associated Protein (CRTAP)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cartilage Associated Protein (CRTAP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cartilage Associated Protein (CRTAP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cartilage Associated Protein (CRTAP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cartilage Associated Protein (CRTAP)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cartilage Associated Protein (CRTAP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cartilage Associated Protein (CRTAP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cartilage Associated Protein (CRTAP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cartilage Associated Protein (CRTAP)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cartilage Associated Protein (CRTAP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cartilage Associated Protein (CRTAP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cartilage Associated Protein (CRTAP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cartilage Associated Protein (CRTAP)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cartilage Associated Protein (CRTAP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cartilage Associated Protein (CRTAP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cartilage Associated Protein (CRTAP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cartilage Associated Protein (CRTAP)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cartilage Associated Protein (CRTAP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cartilage Associated Protein (CRTAP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cartilage Associated Protein (CRTAP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cartilage Associated Protein (CRTAP)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cartilage Associated Protein (CRTAP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cartilage Associated Protein (CRTAP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cartilage Associated Protein (CRTAP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cartilage Associated Protein (CRTAP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cartilage Associated Protein (CRTAP)	CLIA assay for Antigen Detection

Reference

"cDNA cloning, characterization and chromosome mapping of the gene encoding human cartilage associated protein (CRTAP)."
Cytogenet. Cell Genet. 87:191-194(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"CRTAP is required for prolyl 3-hydroxylation and mutations cause recessive osteogenesis imperfecta."
Cell 127:291-304(2006) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Deficiency of CRTAP in non-lethal recessive osteogenesis imperfecta reduces collagen deposition into matrix."
Clin. Genet. 82:453-459(2012) [PubMed] [Europe PMC] [Abstract]

"CRTAP and LEPRE1 mutations in recessive osteogenesis imperfecta."
Hum. Mutat. 29:1435-1442(2008) [PubMed] [Europe PMC] [Abstract]

"CRTAP mutations in lethal and severe osteogenesis imperfecta: the importance of combining biochemical and molecular genetic analysis."
Eur. J. Hum. Genet. 17:1560-1569(2009) [PubMed] [Europe PMC] [Abstract]