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Cornulin (CRNN)

SEP53; C1orf10; DRC1; PDRC1; 53 kDa putative calcium-binding protein; Squamous epithelial heat shock protein 53; Tumor-related protein; 58 kDa heat shock protein

Cornulin is a member of the 'fused gene' family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation.
The C1ORF10 cDNA encodes a deduced 490-amino acid protein with 1 transmembrane domain, an N-terminal EF-hand calcium-binding motif of about 90 amino acids that shares 25 to 35% identity to human S100 calcium-binding proteins, and a conserved consecutive repeat sequence of about 60 amino acids.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO406Hu01 Recombinant Cornulin (CRNN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO406Hu01 Monoclonal Antibody to Cornulin (CRNN) WB; IHC; ICC; IP.
PAO406Hu01 Polyclonal Antibody to Cornulin (CRNN) WB; IHC; ICC; IF.
Assay Kits CLO406Hu01 CLIA Kit for Cornulin (CRNN) CLIA assay for Antigen Detection
ELO406Hu01 ELISA Kit for Cornulin (CRNN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO406Mu01 Recombinant Cornulin (CRNN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO406Mu01 Monoclonal Antibody to Cornulin (CRNN) WB; IHC; ICC; IP.
PAO406Mu01 Polyclonal Antibody to Cornulin (CRNN) WB; IHC; ICC; IF.
Assay Kits CLO406Mu01 CLIA Kit for Cornulin (CRNN) CLIA assay for Antigen Detection
ELO406Mu01 ELISA Kit for Cornulin (CRNN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO406Ra01 Recombinant Cornulin (CRNN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO406Ra01 Monoclonal Antibody to Cornulin (CRNN) WB; IHC; ICC; IP.
PAO406Ra01 Polyclonal Antibody to Cornulin (CRNN) WB; IHC; ICC; IF.
Assay Kits CLO406Ra01 CLIA Kit for Cornulin (CRNN) CLIA assay for Antigen Detection
ELO406Ra01 ELISA Kit for Cornulin (CRNN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO406Ca01 Recombinant Cornulin (CRNN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO406Ca01 Monoclonal Antibody to Cornulin (CRNN) WB; IHC; ICC; IP.
PAO406Ca01 Polyclonal Antibody to Cornulin (CRNN) WB; IHC; ICC; IF.
Assay Kits CLO406Ca01 CLIA Kit for Cornulin (CRNN) CLIA assay for Antigen Detection
ELO406Ca01 ELISA Kit for Cornulin (CRNN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO406Po01 Recombinant Cornulin (CRNN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO406Po01 Monoclonal Antibody to Cornulin (CRNN) WB; IHC; ICC; IP.
PAO406Po01 Polyclonal Antibody to Cornulin (CRNN) WB; IHC; ICC; IF.
Assay Kits CLO406Po01 CLIA Kit for Cornulin (CRNN) CLIA assay for Antigen Detection
ELO406Po01 ELISA Kit for Cornulin (CRNN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO406Bo01 Recombinant Cornulin (CRNN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO406Bo01 Monoclonal Antibody to Cornulin (CRNN) WB; IHC; ICC; IP.
PAO406Bo01 Polyclonal Antibody to Cornulin (CRNN) WB; IHC; ICC; IF.
Assay Kits CLO406Bo01 CLIA Kit for Cornulin (CRNN) CLIA assay for Antigen Detection
ELO406Bo01 ELISA Kit for Cornulin (CRNN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO406Rb01 Recombinant Cornulin (CRNN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO406Rb01 Monoclonal Antibody to Cornulin (CRNN) WB; IHC; ICC; IP.
PAO406Rb01 Polyclonal Antibody to Cornulin (CRNN) WB; IHC; ICC; IF.
Assay Kits CLO406Rb01 CLIA Kit for Cornulin (CRNN) CLIA assay for Antigen Detection
ELO406Rb01 ELISA Kit for Cornulin (CRNN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO406Mo01 Recombinant Cornulin (CRNN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO406Mo01 Monoclonal Antibody to Cornulin (CRNN) WB; IHC; ICC; IP.
PAO406Mo01 Polyclonal Antibody to Cornulin (CRNN) WB; IHC; ICC; IF.
Assay Kits CLO406Mo01 CLIA Kit for Cornulin (CRNN) CLIA assay for Antigen Detection
ELO406Mo01 ELISA Kit for Cornulin (CRNN) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Novel human esophagus-specific gene c1orf10: cDNA cloning, gene structure, and frequent loss of expression in esophageal cancer."
Genomics 69:322-330(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The human oesophageal squamous epithelium exhibits a novel type of heat shock protein response."
Eur. J. Biochem. 268:5343-5355(2001) [PubMed] [Europe PMC] [Abstract]

"Chromosome 1 open reading frame 10 (C1orf10) gene is frequently down-regulated and inhibits cell proliferation in oral squamous cell carcinoma."
Int. J. Biochem. Cell Biol. 37:1641-1655(2005) [PubMed] [Europe PMC] [Abstract]

"Cornulin, a new member of the 'fused gene' family, is expressed during epidermal differentiation."
J. Invest. Dermatol. 124:990-997(2005) [PubMed] [Europe PMC] [Abstract]

"Effect of pepsin on laryngeal stress protein (Sep70, Sep53, and Hsp70) response: role in laryngopharyngeal reflux disease."
Ann. Otol. Rhinol. Laryngol. 115:47-58(2006) [PubMed] [Europe PMC] [Abstract]

"The calcium-binding domain of the stress protein SEP53 is required for survival in response to deoxycholic acid-mediated injury."
FEBS J. 273:1930-1947(2006) [PubMed] [Europe PMC] [Abstract]

"Decreased expression of gene cluster at chromosome 1q21 defines molecular subgroups of chemoradiotherapy response in esophageal cancers."
Clin. Cancer Res. 13:912-919(2007) [PubMed] [Europe PMC] [Abstract]