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Coactosin Like Protein 1 (COTL1)

CLP

COTL1 encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.the 2.0-kb CLP transcript is expressed predominantly in placenta, lung, and kidney, with lower levels in brain, liver, and pancreas. In heart, they detected an additional band of 1.4 kb. In immune tissues, highest expression of CLP was in peripheral blood leukocytes, with lower levels in spleen and lymph node.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins O394Hu01 Recombinant Coactosin Like Protein 1 (COTL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Coactosin Like Protein 1 (COTL1) Bioactivity
Antibodies MO394Hu21 Monoclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IP.
PO394Hu01 Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry;ICC/IF
Assay Kits KEO394Hu ELISA Kit for Coactosin Like Protein 1 (COTL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Coactosin Like Protein 1 (COTL1) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Coactosin Like Protein 1 (COTL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Coactosin Like Protein 1 (COTL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Coactosin Like Protein 1 (COTL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Coactosin Like Protein 1 (COTL1) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Coactosin Like Protein 1 (COTL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Coactosin Like Protein 1 (COTL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Coactosin Like Protein 1 (COTL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Coactosin Like Protein 1 (COTL1) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Coactosin Like Protein 1 (COTL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Coactosin Like Protein 1 (COTL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Coactosin Like Protein 1 (COTL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Coactosin Like Protein 1 (COTL1) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Coactosin Like Protein 1 (COTL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Coactosin Like Protein 1 (COTL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Coactosin Like Protein 1 (COTL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Coactosin Like Protein 1 (COTL1) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Coactosin Like Protein 1 (COTL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Coactosin Like Protein 1 (COTL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Coactosin Like Protein 1 (COTL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Coactosin Like Protein 1 (COTL1) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Coactosin Like Protein 1 (COTL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Coactosin Like Protein 1 (COTL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Coactosin Like Protein 1 (COTL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Coactosin Like Protein 1 (COTL1) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Coactosin Like Protein 1 (COTL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Coactosin Like Protein 1 (COTL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Coactosin Like Protein 1 (COTL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Coactosin Like Protein 1 (COTL1) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Coactosin Like Protein 1 (COTL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Coactosin Like Protein 1 (COTL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Coactosin Like Protein 1 (COTL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Coactosin Like Protein 1 (COTL1) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Coactosin Like Protein 1 (COTL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Coactosin Like Protein 1 (COTL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Coactosin Like Protein 1 (COTL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Coactosin Like Protein 1 (COTL1) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Coactosin Like Protein 1 (COTL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Coactosin Like Protein 1 (COTL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Coactosin Like Protein 1 (COTL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Coactosin Like Protein 1 (COTL1) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Coactosin Like Protein 1 (COTL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Coactosin Like Protein 1 (COTL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Coactosin Like Protein 1 (COTL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Coactosin Like Protein 1 (COTL1) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Coactosin Like Protein 1 (COTL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Coactosin Like Protein 1 (COTL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Coactosin Like Protein 1 (COTL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Coactosin Like Protein 1 (COTL1) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Coactosin Like Protein 1 (COTL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Coactosin Like Protein 1 (COTL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Coactosin Like Protein 1 (COTL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Coactosin Like Protein 1 (COTL1) CLIA assay for Antigen Detection

Reference

"Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome."
Nat. Genet. 17:154-163(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

, Submitted (MAR-2007) to UniProtKB

"Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75."
Biochem. J. 359:255-263(2001) [PubMed] [Europe PMC] [Abstract]

"5-lipoxygenase interacts with coactosin-like protein."
J. Biol. Chem. 276:16520-16527(2001) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102."
Biochem. J. 425:265-274(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"NMR structure of human coactosin-like protein."
J. Biomol. NMR 30:353-356(2004) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human coactosin-like protein at 1.9 A resolution."
Protein Sci. 13:2845-2851(2004) [PubMed] [Europe PMC] [Abstract]

"Binding model of human coactosin-like protein with filament actin revealed by mutagenesis."
Biochim. Biophys. Acta 1764:1688-1700(2006) [PubMed] [Europe PMC] [Abstract]