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Chitinase 1 (CHIT1)
Chitinase 1 (CHIT1)
CHI3; Chitotriosidase
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture.
Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. The findings suggested that a single gene encodes the different isoforms of chitotriosidase. The authors postulated that the enzyme may be involved in defense against and in degradation of chitin-containing pathogens such as fungi, nematodes, and insects.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
O373Hu01
Recombinant Chitinase 1 (CHIT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chitinase 1 (CHIT1) Bioactivity
Antibodies
MO373Hu21
Monoclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IP.
PO373Hu01
Polyclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IF.
LO373Hu71
Biotin Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chitinase 1 (CHIT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chitinase 1 (CHIT1) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
O373Mu01
Recombinant Chitinase 1 (CHIT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chitinase 1 (CHIT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IP.
PO373Mu01
Polyclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry;ICC/IF
Assay Kits
KEO373Mu
ELISA Kit for Chitinase 1 (CHIT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chitinase 1 (CHIT1) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chitinase 1 (CHIT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chitinase 1 (CHIT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IP.
PO373Ra01
Polyclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chitinase 1 (CHIT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chitinase 1 (CHIT1) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chitinase 1 (CHIT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chitinase 1 (CHIT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chitinase 1 (CHIT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chitinase 1 (CHIT1) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chitinase 1 (CHIT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chitinase 1 (CHIT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chitinase 1 (CHIT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chitinase 1 (CHIT1) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chitinase 1 (CHIT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chitinase 1 (CHIT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chitinase 1 (CHIT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chitinase 1 (CHIT1) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chitinase 1 (CHIT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chitinase 1 (CHIT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chitinase 1 (CHIT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chitinase 1 (CHIT1) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chitinase 1 (CHIT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chitinase 1 (CHIT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chitinase 1 (CHIT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chitinase 1 (CHIT1) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chitinase 1 (CHIT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chitinase 1 (CHIT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chitinase 1 (CHIT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chitinase 1 (CHIT1) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chitinase 1 (CHIT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chitinase 1 (CHIT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chitinase 1 (CHIT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chitinase 1 (CHIT1) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chitinase 1 (CHIT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chitinase 1 (CHIT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chitinase 1 (CHIT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chitinase 1 (CHIT1) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chitinase 1 (CHIT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chitinase 1 (CHIT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chitinase 1 (CHIT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chitinase 1 (CHIT1) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chitinase 1 (CHIT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chitinase 1 (CHIT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chitinase 1 (CHIT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chitinase 1 (CHIT1) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chitinase 1 (CHIT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chitinase 1 (CHIT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chitinase 1 (CHIT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chitinase 1 (CHIT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chitinase 1 (CHIT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chitinase 1 (CHIT1) CLIA assay for Antigen Detection
Reference
"Cloning of a cDNA encoding chitotriosidase, a human chitinase produced by macrophages." J. Biol. Chem. 270:26252-26256(1995) [PubMed ] [Europe PMC ] [Abstract ]
"Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed ] [Europe PMC ] [Abstract ]
"The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed ] [Europe PMC ] [Abstract ]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14:2121-2127(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Purification and characterization of human chitotriosidase, a novel member of the chitinase family of proteins." J. Biol. Chem. 270:2198-2202(1995) [PubMed ] [Europe PMC ] [Abstract ]
"The human chitotriosidase gene. Nature of inherited enzyme deficiency." J. Biol. Chem. 273:25680-25685(1998) [PubMed ] [Europe PMC ] [Abstract ]
"Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins." J. Biol. Chem. 277:25537-25544(2002) [PubMed ] [Europe PMC ] [Abstract ]
"Crystal structures of allosamidin derivatives in complex with human macrophage chitinase." J. Biol. Chem. 278:20110-20116(2003) [PubMed ] [Europe PMC ] [Abstract ]
"Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases." Chem. Biol. 12:65-76(2005) [PubMed ] [Europe PMC ] [Abstract ]
"Type 1 Gaucher disease: null and hypomorphic novel chitotriosidase mutations-implications for diagnosis and therapeutic monitoring." Hum. Mutat. 28:866-873(2007) [PubMed ] [Europe PMC ] [Abstract ]
"Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates." FEBS J. 276:5678-5688(2009) [PubMed ] [Europe PMC ] [Abstract ]
