Sulfate groups in carbohydrates confer highly specific functions on glycoproteins, glycolipids, and proteoglycans and are critical for cell-cell interaction, signal transduction, and embryonic development. Sulfotransferases, such as CHST9, carry out sulfation of carbohydrates. The full-length protein contains 443 amino acids and has a calculated molecular mass of 52.1 kD. It has a membrane-spanning domain with a type II topology, a stem region, putative 5-prime-phosphosulfonate- and 3-prime-phosphate-binding sites, and 4 potential N-glycosylation sites. GalNAc4ST2 shares 46% amino acid identity with GalNAc4ST1 (CHST8). Synthesis of this protein is initiated from an alternative start codon (met86), and, consequently, it lacks the N-terminal transmembrane domain.
Monoclonal Antibody to Carbohydrate Sulfotransferase 9 (CHST9)
WB; IHC; ICC; IP.
PAO348Mo01
Polyclonal Antibody to Carbohydrate Sulfotransferase 9 (CHST9)
WB; IHC; ICC; IF.
Assay Kits
CLO348Mo01
CLIA Kit for Carbohydrate Sulfotransferase 9 (CHST9)
CLIA assay for Antigen Detection
ELO348Mo01
ELISA Kit for Carbohydrate Sulfotransferase 9 (CHST9)
Enzyme-linked immunosorbent assay for Antigen Detection
Reference
"Molecular cloning and expression of two distinct human N-acetylgalactosamine 4-O-sulfotransferases that transfer sulfate to GalNAc beta 1->4GlcNAc beta 1->R in both N- and O-glycans." Glycobiology 11:495-504(2001) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning and expression of an N-acetylgalactosamine-4-O-sulfotransferase that transfers sulfate to terminal and non-terminal beta 1,4-linked N-acetylgalactosamine." J. Biol. Chem. 276:10861-10869(2001) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
