Translocator Protein (TSPO)
IBP; PKBS; PBR; pk18; mDRC; MBR; BZRP; DBI; PTBR; Mitochondrial benzodiazepine receptor; Peripheral-Type Benzodiazepine Receptor/Recognition Site
TSPO) is an 18 kDa protein of the outer mitochondrial membrane. It was a secondary binding site for diazepam, but subsequent research has found the receptor to be expressed throughout the body and brain.
TSPO has been shown to be involved in a number of processes such as inflammation, and TSPO ligands may be useful anti-cancer drugs. Activation of TSPO is also required for steroidogenesis to take place, and this is particularly important for the production of neuroactive steroids such as allopregnanolone in the brain. This makes some TSPO ligands such as emapunil (XBD-173) useful as potential anxiolytics which may have less side effects than traditional benzodiazepine-type drugs.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | O226Hu01 | Recombinant Translocator Protein (TSPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Translocator Protein (TSPO) | Bioactivity | |
| Antibodies | MO226Hu21 | Monoclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IP. |
| PO226Hu01 | Polyclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Translocator Protein (TSPO) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEO226Hu | ELISA Kit for Translocator Protein (TSPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Translocator Protein (TSPO) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Translocator Protein (TSPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Translocator Protein (TSPO) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Translocator Protein (TSPO) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Translocator Protein (TSPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Translocator Protein (TSPO) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Translocator Protein (TSPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Translocator Protein (TSPO) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Translocator Protein (TSPO) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Translocator Protein (TSPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Translocator Protein (TSPO) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Translocator Protein (TSPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Translocator Protein (TSPO) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Translocator Protein (TSPO) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Translocator Protein (TSPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Translocator Protein (TSPO) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Translocator Protein (TSPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Translocator Protein (TSPO) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Translocator Protein (TSPO) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Translocator Protein (TSPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Translocator Protein (TSPO) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Translocator Protein (TSPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Translocator Protein (TSPO) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Translocator Protein (TSPO) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Translocator Protein (TSPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Translocator Protein (TSPO) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Translocator Protein (TSPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Translocator Protein (TSPO) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Translocator Protein (TSPO) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Translocator Protein (TSPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Translocator Protein (TSPO) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Translocator Protein (TSPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Translocator Protein (TSPO) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Translocator Protein (TSPO) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Translocator Protein (TSPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Translocator Protein (TSPO) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Translocator Protein (TSPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Translocator Protein (TSPO) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Translocator Protein (TSPO) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Translocator Protein (TSPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Translocator Protein (TSPO) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Translocator Protein (TSPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Translocator Protein (TSPO) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Translocator Protein (TSPO) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Translocator Protein (TSPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Translocator Protein (TSPO) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Translocator Protein (TSPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Translocator Protein (TSPO) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Translocator Protein (TSPO) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Translocator Protein (TSPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Translocator Protein (TSPO) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Translocator Protein (TSPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Translocator Protein (TSPO) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Translocator Protein (TSPO) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Translocator Protein (TSPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Translocator Protein (TSPO) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Translocator Protein (TSPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Translocator Protein (TSPO) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Translocator Protein (TSPO) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Translocator Protein (TSPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Translocator Protein (TSPO) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Translocator Protein (TSPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Translocator Protein (TSPO) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Translocator Protein (TSPO) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Translocator Protein (TSPO) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Translocator Protein (TSPO) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Translocator Protein (TSPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Translocator Protein (TSPO) | CLIA assay for Antigen Detection |
Reference
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Eur. J. Biochem. 195:305-311(1991) [PubMed] [Europe PMC] [Abstract]
"Comparison of repetitive elements in the third intron of human and rodent mitochondrial benzodiazepine receptor-encoding genes."
Gene 155:201-205(1995) [PubMed] [Europe PMC] [Abstract]
"Peripheral benzodiazepine receptor: characterization in human T-lymphoma Jurkat cells."
Mol. Pharmacol. 69:37-44(2006) [PubMed] [Europe PMC] [Abstract]
"A genome annotation-driven approach to cloning the human ORFeome."
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor."
J. Biol. Chem. 274:2938-2952(1999) [PubMed] [Europe PMC] [Abstract]
"Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function."
Trends Pharmacol. Sci. 27:402-409(2006) [PubMed] [Europe PMC] [Abstract]
"Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers."
Int. J. Oncol. 30:81-89(2007) [PubMed] [Europe PMC] [Abstract]
"Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states."
Mol. Cell. Endocrinol. 327:1-12(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Targeting mitochondrial 18kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype."
Clin. Sci. 127:603-613(2014) [PubMed] [Europe PMC] [Abstract]
"An association study between two missense variations of the benzodiazepine receptor (peripheral) gene and schizophrenia in a Japanese sample."
J. Neural Transm. 107:491-500(2000) [PubMed] [Europe PMC] [Abstract]
"No association of two missense variations of the benzodiazepine receptor (peripheral) gene and mood disorders in a Japanese sample."
Am. J. Med. Genet. 105:172-175(2001) [PubMed] [Europe PMC] [Abstract]
"The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals."
Endocrinology 150:5438-5445(2009) [PubMed] [Europe PMC] [Abstract]