Biliverdin Reductase B (BLVRB)

FLR; SDR43U1; Flavin Reductase,NADPH; Short Chain Dehydrogenase/Reductase Family 43U,Member 1; Biliverdin-IX beta-reductase; Green heme-binding protein

SPN	O209
HGNC	1063
MGI	2385271
PubMed	21478226
RGD	1306080
UniProt	P30043

The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B. BLVRB is found predominantly in fetal liver. BLVRA is a major component of human adult liver and is identical to the enzyme previously reported as biliverdin reductase.

The FLR cDNA, which appeared to be identical to the BLVRB cDNA, encodes a deduced 206-amino acid protein. Western blot analysis of rat tissues showed highest levels of FLR in the erythrocytes and liver. Northern blot analysis detected a 1.1-kb transcript in human tissues. that flavins are the effective electron acceptor of the enzyme and purified FLR to homogeneity.

Reference

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Biochem. Biophys. Res. Commun. 198:1170-1176(1994) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and expression of human liver biliverdin-IXbeta reductase."
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"Complete amino acid sequence of biliverdin-IX beta reductase from human liver."
Biochem. Biophys. Res. Commun. 197:1518-1523(1993) [PubMed] [Europe PMC] [Abstract]

"Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from human liver. Purification and characterization."
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, Submitted (DEC-2008) to UniProtKB

"Evidence that biliverdin-IX beta reductase and flavin reductase are identical."
Biochem. J. 316:385-387(1996) [PubMed] [Europe PMC] [Abstract]

"Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B)."
Biochem. J. 345:393-399(2000) [PubMed] [Europe PMC] [Abstract]

"Computational and experimental studies on the catalytic mechanism of biliverdin-IXbeta reductase."
Biochem. J. 411:475-484(2008) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme."
Nat. Struct. Biol. 8:215-220(2001) [PubMed] [Europe PMC] [Abstract]