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Biliverdin Reductase A (BLVRA)

BLVR; BVR; Biliverdin-IX alpha-reductase

Biliverdin reductases, such as BLVRA (EC 1.3.1.24), catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH.
The deduced 296-amino acid protein has a calculated molecular mass of 33.2 kD. Removal of 2 N-terminal amino acids results in a 294-amino acid mature protein with an N-terminal threonine. The N-terminal region contains the NADH/NADPH-binding consensus sequence. BLVRA shares 82.8% amino acid identity with rat Blvra, but it does not share significant homology with BLVRB. Northern blot analysis detected BLVRA at 1.35 kb in all 8 tissues examined. Expression was highest in brain, pancreas, and lung, and lowest in liver and placenta.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO208Hu01 Recombinant Biliverdin Reductase A (BLVRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO208Hu01 Monoclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IP.
PAO208Hu01 Polyclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IF.
Assay Kits CLO208Hu01 CLIA Kit for Biliverdin Reductase A (BLVRA) CLIA assay for Antigen Detection
ELO208Hu01 ELISA Kit for Biliverdin Reductase A (BLVRA) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO208Mu01 Recombinant Biliverdin Reductase A (BLVRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO208Mu01 Monoclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IP.
PAO208Mu01 Polyclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IF.
Assay Kits CLO208Mu01 CLIA Kit for Biliverdin Reductase A (BLVRA) CLIA assay for Antigen Detection
ELO208Mu01 ELISA Kit for Biliverdin Reductase A (BLVRA) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO208Ra01 Recombinant Biliverdin Reductase A (BLVRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO208Ra01 Monoclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IP.
PAO208Ra01 Polyclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IF.
Assay Kits CLO208Ra01 CLIA Kit for Biliverdin Reductase A (BLVRA) CLIA assay for Antigen Detection
ELO208Ra01 ELISA Kit for Biliverdin Reductase A (BLVRA) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO208Ca01 Recombinant Biliverdin Reductase A (BLVRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO208Ca01 Monoclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IP.
PAO208Ca01 Polyclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IF.
Assay Kits CLO208Ca01 CLIA Kit for Biliverdin Reductase A (BLVRA) CLIA assay for Antigen Detection
ELO208Ca01 ELISA Kit for Biliverdin Reductase A (BLVRA) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO208Po01 Recombinant Biliverdin Reductase A (BLVRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO208Po01 Monoclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IP.
PAO208Po01 Polyclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IF.
Assay Kits CLO208Po01 CLIA Kit for Biliverdin Reductase A (BLVRA) CLIA assay for Antigen Detection
ELO208Po01 ELISA Kit for Biliverdin Reductase A (BLVRA) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO208Bo01 Recombinant Biliverdin Reductase A (BLVRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO208Bo01 Monoclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IP.
PAO208Bo01 Polyclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IF.
Assay Kits CLO208Bo01 CLIA Kit for Biliverdin Reductase A (BLVRA) CLIA assay for Antigen Detection
ELO208Bo01 ELISA Kit for Biliverdin Reductase A (BLVRA) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO208Rb01 Recombinant Biliverdin Reductase A (BLVRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO208Rb01 Monoclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IP.
PAO208Rb01 Polyclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IF.
Assay Kits CLO208Rb01 CLIA Kit for Biliverdin Reductase A (BLVRA) CLIA assay for Antigen Detection
ELO208Rb01 ELISA Kit for Biliverdin Reductase A (BLVRA) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO208Mo01 Recombinant Biliverdin Reductase A (BLVRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO208Mo01 Monoclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IP.
PAO208Mo01 Polyclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IF.
Assay Kits CLO208Mo01 CLIA Kit for Biliverdin Reductase A (BLVRA) CLIA assay for Antigen Detection
ELO208Mo01 ELISA Kit for Biliverdin Reductase A (BLVRA) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning and characterization of the cDNA encoding human biliverdin-IX alpha reductase."
Biochim. Biophys. Acta 1309:89-99(1996) [PubMed] [Europe PMC] [Abstract]

"Human biliverdin IXalpha reductase is a zinc-metalloprotein. Characterization of purified and Escherichia coli expressed enzymes."
Eur. J. Biochem. 235:372-381(1996) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of human biliverdin reductase."
Arch. Biochem. Biophys. 300:320-326(1993) [PubMed] [Europe PMC] [Abstract]

"Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from human liver. Purification and characterization."
J. Biol. Chem. 269:24343-24348(1994) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"A novel mutation in the biliverdin reductase-A gene combined with liver cirrhosis results in hyperbiliverdinaemia (green jaundice)."
Liver Int. 29:1116-1124(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human biliverdin reductase A."
Submitted (FEB-2009) to the PDB data bank