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Bridging Integrator 2 (BIN2)
Bridging Integrator 2 (BIN2)
BRAP-1; Breast cancer-associated protein 1
BIN2 has acidic and serine/proline-rich stretches but lacks a C-terminal SH3 domain or a MYC-interacting region. Northern blot analysis revealed expression of a major 2.6-kb transcript that was highest in spleen and peripheral blood leukocytes and also high in thymus, colon, and placenta, suggesting preferential expression in hematopoietic tissues. Strong expression was detected in lymphoid and granulocytic cell lines but not other cell lines. Coimmunoprecipitation and Western blot analyses showed expression of an 80-kD protein that interacts with the N-terminal portion of the BAR domain of BIN1 isoforms but not with AMPH. Immunofluorescence microscopy demonstrated cytosolic expression and lack of receptor-mediated endocytic function for BIN2. Functional analysis showed that BIN2 lacks tumor suppressor features.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
O205Hu01
Recombinant Bridging Integrator 2 (BIN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Bridging Integrator 2 (BIN2) Bioactivity
Antibodies
MO205Hu21
Monoclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IP.
PO205Hu01
Polyclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry;ICC/IF
Assay Kits
KEO205Hu
ELISA Kit for Bridging Integrator 2 (BIN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Bridging Integrator 2 (BIN2) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Bridging Integrator 2 (BIN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Bridging Integrator 2 (BIN2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Bridging Integrator 2 (BIN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Bridging Integrator 2 (BIN2) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Bridging Integrator 2 (BIN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Bridging Integrator 2 (BIN2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Bridging Integrator 2 (BIN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Bridging Integrator 2 (BIN2) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Bridging Integrator 2 (BIN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Bridging Integrator 2 (BIN2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Bridging Integrator 2 (BIN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Bridging Integrator 2 (BIN2) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Bridging Integrator 2 (BIN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Bridging Integrator 2 (BIN2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Bridging Integrator 2 (BIN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Bridging Integrator 2 (BIN2) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Bridging Integrator 2 (BIN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Bridging Integrator 2 (BIN2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Bridging Integrator 2 (BIN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Bridging Integrator 2 (BIN2) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Bridging Integrator 2 (BIN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Bridging Integrator 2 (BIN2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Bridging Integrator 2 (BIN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Bridging Integrator 2 (BIN2) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Bridging Integrator 2 (BIN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Bridging Integrator 2 (BIN2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Bridging Integrator 2 (BIN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Bridging Integrator 2 (BIN2) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Bridging Integrator 2 (BIN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Bridging Integrator 2 (BIN2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Bridging Integrator 2 (BIN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Bridging Integrator 2 (BIN2) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Bridging Integrator 2 (BIN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Bridging Integrator 2 (BIN2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Bridging Integrator 2 (BIN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Bridging Integrator 2 (BIN2) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Bridging Integrator 2 (BIN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Bridging Integrator 2 (BIN2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Bridging Integrator 2 (BIN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Bridging Integrator 2 (BIN2) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Bridging Integrator 2 (BIN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Bridging Integrator 2 (BIN2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Bridging Integrator 2 (BIN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Bridging Integrator 2 (BIN2) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Bridging Integrator 2 (BIN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Bridging Integrator 2 (BIN2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Bridging Integrator 2 (BIN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Bridging Integrator 2 (BIN2) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Bridging Integrator 2 (BIN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Bridging Integrator 2 (BIN2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Bridging Integrator 2 (BIN2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Bridging Integrator 2 (BIN2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Bridging Integrator 2 (BIN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Bridging Integrator 2 (BIN2) CLIA assay for Antigen Detection
Reference
"Bin2, a functionally nonredundant member of the BAR adaptor gene family." Genomics 67:210-220(2000) [PubMed ] [Europe PMC ] [Abstract ]
"Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed ] [Europe PMC ] [Abstract ]
"The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed ] [Europe PMC ] [Abstract ]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14:2121-2127(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." J. Proteome Res. 7:5167-5176(2008) [PubMed ] [Europe PMC ] [Abstract ]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Sci. Signal. 2:RA46-RA46(2009) [PubMed ] [Europe PMC ] [Abstract ]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome." J. Proteomics 96:253-262(2014) [PubMed ] [Europe PMC ] [Abstract ]
"Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis." PLoS ONE 7:E52401-E52401(2012) [PubMed ] [Europe PMC ] [Abstract ]
