Bridging Integrator 1 (BIN1)

AMPH2; AMPHL; SH3P9; Amphiphysin II; Myc Box-Dependent-Interacting Protein 1; Amphiphysin-like protein

SPN	O204
HGNC	1052
MGI	108092
PubMed	8725406
RGD	621786
UniProt	O00499
Wiki	BIN1

BIN1 encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Reference

"Identification and characterization of a nerve terminal-enriched amphiphysin isoform."
J. Biol. Chem. 272:16700-16706(1997) [PubMed] [Europe PMC] [Abstract]

"Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of Ranvier in brain and around T tubules in skeletal muscle."
J. Cell Biol. 137:1355-1367(1997) [PubMed] [Europe PMC] [Abstract]

"BIN1 is a novel Myc-interacting protein with features of a tumour suppressor."
Nat. Genet. 14:69-76(1996) [PubMed] [Europe PMC] [Abstract]

"Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites."
J. Neurochem. 70:2369-2376(1998) [PubMed] [Europe PMC] [Abstract]

"cDNA cloning of a novel amphiphysin isoform and tissue-specific expression of its multiple splice variants."
Biochem. Biophys. Res. Commun. 236:178-183(1997) [PubMed] [Europe PMC] [Abstract]

"Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing."
J. Biol. Chem. 272:31453-31458(1997) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"A role for the putative tumor suppressor Bin1 in muscle cell differentiation."
Mol. Cell. Biol. 18:566-575(1998) [PubMed] [Europe PMC] [Abstract]

"Bin2, a functionally nonredundant member of the BAR adaptor gene family."
Genomics 67:210-220(2000) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"The SH3 binding motif of HCV NS5A protein interacts with Bin1 and is important for apoptosis and infectivity."
Gastroenterology 130:794-809(2006) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy."
Nat. Genet. 39:1134-1139(2007) [PubMed] [Europe PMC] [Abstract]