Alkaline Phosphatase, Placental Like Protein 2 (ALPPL2)

ALPG; GCAP; ALP-1; Alkaline phosphatase Nagao isozyme; Germ cell alkaline phosphatase; Placental alkaline phosphatase-like

SPN	O115
HGNC	441
MGI	108009
PubMed	23467613
RGD	1565100
UniProt	P10696
Wiki	ALPPL2

Cloning and sequencing of the placental alkaline phosphatase, intestinal alkaline phosphatase, and germ-cell alkaline phosphatase genes indicate a high degree of homology; in particular, 98% amino acid sequence identity has been demonstrated between placental and germ-cell forms of the enzyme.

ALPPL1 encodes the classic heat-stabile placental alkaline phosphatase; ALPPL2 is closely related to the first, and may encode the so-called placental ALP-like enzyme of the testis and thymus; the third member of this gene family, the intestinal ALP gene, encodes intestinal alkaline phosphatase. The expression of the intestinal and placental genes is highly tissue-specific in spite of nearly 90% sequence similarity within their exons.

Reference

"Seminoma-derived Nagao isozyme is encoded by a germ-cell alkaline phosphatase gene."
Proc. Natl. Acad. Sci. U.S.A. 85:3024-3028(1988) [PubMed] [Europe PMC] [Abstract]

"Expression of the germ cell alkaline phosphatase gene in human choriocarcinoma cells."
J. Biol. Chem. 264:12611-12619(1989) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of complementary DNAs encoding alkaline phosphatase in human colon cancer cells."
Cancer Res. 50:1085-1091(1990) [PubMed] [Europe PMC] [Abstract]

"Expression of a Nagao-type, phosphatidylinositol-glycan anchored alkaline phosphatase in human choriocarcinomas."
Cancer Res. 50:3956-3962(1990) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases."
Gene 60:267-276(1987) [PubMed] [Europe PMC] [Abstract]

"5' nucleotide sequence of a putative human placental alkaline phosphatase-like gene."
Nucleic Acids Res. 16:5694-5694(1988) [PubMed] [Europe PMC] [Abstract]