AE Binding Protein 1 (AEBP1)

ACLP; Aortic Carboxypeptidase-Like Protein; Adipocyte Enhancer Binding Protein 1

SPN	O096
HGNC	303
MGI	1197012
PubMed	22995915
RGD	1306922
UniProt	Q8IUX7

AEBP1 binds to a regulatory sequence, adipocyte enhancer 1 (AE-1), located in the proximal promoter region of the adipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. It is characterized as a member of the regulatory B-like CP family. This protein seems to be activated by a novel mechanism, whereby the direct binding of DNA enhances its protease activity. Adipocyte-enhancer binding protein 1 may play a role in differentiated vascular smooth muscle cells. The deduced 1,158-amino acid ACLP protein contains a putative signal peptide; an 11-residue lys/pro-rich motif repeated 4 times in the N terminus; a domain with 30% identity to the slime mold adhesion protein discoidin I; and a C-terminal 500-amino acid domain with 39% identity to carboxypeptidase E (CPE).

Reference

"Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation."
J. Biol. Chem. 273:15654-15660(1998) [PubMed] [Europe PMC] [Abstract]

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Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A cDNA cloning of human AEBP1 from primary cultured osteoblasts and its expression in a differentiating osteoblastic cell line."
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J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]