Aconitase 1 (ACO1)
IREB1; IRP1; IREBP; Iron regulatory protein 1; Iron-responsive element-binding protein 1; Cytoplasmic aconitate hydratase; Citrate hydro-lyase; Ferritin repressor protein
Aconitase 1 is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. The cytoplasmic IREBP interacts with the IREs of these mRNAs. The iron status of the cell determines the ability of IREBP to bind to an IRE through reversible oxidation-reduction of sulfhydryl groups that are critical for the high-affinity RNA-protein interaction. Thus, IREBP plays a central role in cellular iron homeostasis by regulating ferritin mRNA translation and TFRC mRNA stability
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | O081Hu01 | Recombinant Aconitase 1 (ACO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Aconitase 1 (ACO1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IP. |
| PO081Hu01 | Polyclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IF. | |
| LO081Hu71 | Biotin Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEO081Hu | ELISA Kit for Aconitase 1 (ACO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Aconitase 1 (ACO1) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Aconitase 1 (ACO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Aconitase 1 (ACO1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IP. |
| PO081Mu01 | Polyclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IF. | |
| LO081Mu71 | Biotin Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Aconitase 1 (ACO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Aconitase 1 (ACO1) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | O081Ra01 | Recombinant Aconitase 1 (ACO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Aconitase 1 (ACO1) | Bioactivity | |
| Antibodies | MO081Ra21 | Monoclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IP. |
| PO081Ra01 | Polyclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEO081Ra | ELISA Kit for Aconitase 1 (ACO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Aconitase 1 (ACO1) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Aconitase 1 (ACO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Aconitase 1 (ACO1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Aconitase 1 (ACO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Aconitase 1 (ACO1) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Aconitase 1 (ACO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Aconitase 1 (ACO1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Aconitase 1 (ACO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Aconitase 1 (ACO1) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Aconitase 1 (ACO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Aconitase 1 (ACO1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Aconitase 1 (ACO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Aconitase 1 (ACO1) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Aconitase 1 (ACO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Aconitase 1 (ACO1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Aconitase 1 (ACO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Aconitase 1 (ACO1) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Aconitase 1 (ACO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Aconitase 1 (ACO1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Aconitase 1 (ACO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Aconitase 1 (ACO1) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Aconitase 1 (ACO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Aconitase 1 (ACO1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Aconitase 1 (ACO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Aconitase 1 (ACO1) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Aconitase 1 (ACO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Aconitase 1 (ACO1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Aconitase 1 (ACO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Aconitase 1 (ACO1) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Aconitase 1 (ACO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Aconitase 1 (ACO1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Aconitase 1 (ACO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Aconitase 1 (ACO1) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Aconitase 1 (ACO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Aconitase 1 (ACO1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Aconitase 1 (ACO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Aconitase 1 (ACO1) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Aconitase 1 (ACO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Aconitase 1 (ACO1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Aconitase 1 (ACO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Aconitase 1 (ACO1) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Aconitase 1 (ACO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Aconitase 1 (ACO1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Aconitase 1 (ACO1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Aconitase 1 (ACO1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Aconitase 1 (ACO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Aconitase 1 (ACO1) | CLIA assay for Antigen Detection |
Reference
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Nucleic Acids Res. 20:33-39(1992) [PubMed] [Europe PMC] [Abstract]
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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"Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase."
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