Nuclear Distribution Gene C Homolog (NUDC)

HNUDC; MNUDC; NPD011

SPN	O051
HGNC	8045
MGI	106014
PubMed	12852857
RGD	3215
UniProt	Q9Y266
Wiki	NUDC

NudC was first identified as a regulator of nuclear movement in the asexual reproductive cycle of the filamentous fungus Aspergillus nidulans. Human NUDC is a nuclear movement protein that associates with dynein.

The deduced 331-amino acid protein contains a basic stretch from lys68 to arg76, an acidic region from asp144 to asp155, and a 94-amino acid C terminus that is highly homologous to A. nidulans NudC. Human NUDC shares 94% and 95% amino acid identity with mouse and rat NudC, respectively.Expression was primarily cytoplasmic, although punctate nuclear staining was also observed. In cultured human erythroid cells, NUDC mRNA and protein were highly expressed in rapidly proliferating cells and declined upon terminal differentiation.

Reference

"A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis."
Exp. Hematol. 27:742-750(1999) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and characterization of the human NUDC gene."
Hum. Genet. 104:498-504(1999) [PubMed] [Europe PMC] [Abstract]

"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A role for Plk1 phosphorylation of NudC in cytokinesis."
Dev. Cell 5:127-138(2003) [PubMed] [Europe PMC] [Abstract]

"Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis."
J. Cell Sci. 116:1991-2003(2003) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]