Interleukin 21 Receptor (IL21R)

CD360; NILR; Novel interleukin receptor

SPN	O029
HGNC	6006
MGI	1890475
PubMed	20072140
RGD	1304950
UniProt	Q9HBE5
Wiki	IL21R

IL21R is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.

Reference

"Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function."
Nature 408:57-63(2000) [PubMed] [Europe PMC] [Abstract]

"Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain."
Proc. Natl. Acad. Sci. U.S.A. 97:11439-11444(2000) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma."
Oncogene 21:368-376(2002) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R."
J. Biol. Chem. 287:9454-9460(2012) [PubMed] [Europe PMC] [Abstract]

"Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome."
J. Exp. Med. 210:433-443(2013) [PubMed] [Europe PMC] [Abstract]