Cbp/p300 Interacting Transactivator, With Glu/Asp Rich Carboxy Terminal Domain 1 (CITED1)

MSG1; Melanocyte-specific protein 1

SPN	N994
HGNC	1986
MGI	108023
PubMed	23935526
RGD	620781
UniProt	Q99966
Wiki	CITED1

MSG1 transcripts in pigmented human epidermal melanocytes but did not detect MSG1 expression in any of the examined depigmented or weakly pigmented human melanoma cells. The deduced 193-amino acid human MSG1 protein shares 75% overall sequence identity with mouse Msg1. The C-terminal 54 amino acids of these proteins are 96% identical and highly acidic, with 22% of the amino acids being either aspartic acid or glutamic acid; this region forms a predicted amphipathic alpha-helical structure. Immunoprecipitation studies using an antibody against Msg1 detected a 27-kD protein in human epidermal melanocyte lysates. Immunofluorescence cytochemistry localized MSG1 to the nucleus of normal human epidermal melanocytes and human melanoma cells.

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