Non POU Domain Containing Octamer Binding Protein (NONO)
P54; NMT55; NRB54; P54NRB; Nuclear RNA-Binding Protein 54-kD; 54 kDa nuclear RNA- and DNA-binding protein; DNA-binding p52/p100 complex, 52 kDa subunit
NONO encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. The reduction of NONO expression by RNA interference (RNAi) attenuated circadian rhythms in mammalian cells, and fruit flies carrying a hypomorphic allele were nearly arrhythmic. WDR5, a subunit of histone methyltransferase complexes, augmented PER-mediated transcriptional repression, and its reduction by RNAi diminished circadian histone methylation at the promoter of a clock gene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN947Hu01 | Recombinant Non POU Domain Containing Octamer Binding Protein (NONO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN947Hu01 | Monoclonal Antibody to Non POU Domain Containing Octamer Binding Protein (NONO) | WB; IHC; ICC; IP. |
| PAN947Hu01 | Polyclonal Antibody to Non POU Domain Containing Octamer Binding Protein (NONO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN947Hu01 | CLIA Kit for Non POU Domain Containing Octamer Binding Protein (NONO) | CLIA assay for Antigen Detection |
| ELN947Hu01 | ELISA Kit for Non POU Domain Containing Octamer Binding Protein (NONO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN947Mu01 | Recombinant Non POU Domain Containing Octamer Binding Protein (NONO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN947Mu01 | Monoclonal Antibody to Non POU Domain Containing Octamer Binding Protein (NONO) | WB; IHC; ICC; IP. |
| PAN947Mu01 | Polyclonal Antibody to Non POU Domain Containing Octamer Binding Protein (NONO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN947Mu01 | CLIA Kit for Non POU Domain Containing Octamer Binding Protein (NONO) | CLIA assay for Antigen Detection |
| ELN947Mu01 | ELISA Kit for Non POU Domain Containing Octamer Binding Protein (NONO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN947Ra01 | Recombinant Non POU Domain Containing Octamer Binding Protein (NONO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN947Ra01 | Monoclonal Antibody to Non POU Domain Containing Octamer Binding Protein (NONO) | WB; IHC; ICC; IP. |
| PAN947Ra01 | Polyclonal Antibody to Non POU Domain Containing Octamer Binding Protein (NONO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN947Ra01 | CLIA Kit for Non POU Domain Containing Octamer Binding Protein (NONO) | CLIA assay for Antigen Detection |
| ELN947Ra01 | ELISA Kit for Non POU Domain Containing Octamer Binding Protein (NONO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN947Ca01 | Recombinant Non POU Domain Containing Octamer Binding Protein (NONO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN947Ca01 | Monoclonal Antibody to Non POU Domain Containing Octamer Binding Protein (NONO) | WB; IHC; ICC; IP. |
| PAN947Ca01 | Polyclonal Antibody to Non POU Domain Containing Octamer Binding Protein (NONO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN947Ca01 | CLIA Kit for Non POU Domain Containing Octamer Binding Protein (NONO) | CLIA assay for Antigen Detection |
| ELN947Ca01 | ELISA Kit for Non POU Domain Containing Octamer Binding Protein (NONO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN947Po01 | Recombinant Non POU Domain Containing Octamer Binding Protein (NONO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN947Po01 | Monoclonal Antibody to Non POU Domain Containing Octamer Binding Protein (NONO) | WB; IHC; ICC; IP. |
| PAN947Po01 | Polyclonal Antibody to Non POU Domain Containing Octamer Binding Protein (NONO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN947Po01 | CLIA Kit for Non POU Domain Containing Octamer Binding Protein (NONO) | CLIA assay for Antigen Detection |
| ELN947Po01 | ELISA Kit for Non POU Domain Containing Octamer Binding Protein (NONO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN947Bo01 | Recombinant Non POU Domain Containing Octamer Binding Protein (NONO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN947Bo01 | Monoclonal Antibody to Non POU Domain Containing Octamer Binding Protein (NONO) | WB; IHC; ICC; IP. |
| PAN947Bo01 | Polyclonal Antibody to Non POU Domain Containing Octamer Binding Protein (NONO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN947Bo01 | CLIA Kit for Non POU Domain Containing Octamer Binding Protein (NONO) | CLIA assay for Antigen Detection |
| ELN947Bo01 | ELISA Kit for Non POU Domain Containing Octamer Binding Protein (NONO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN947Rb01 | Recombinant Non POU Domain Containing Octamer Binding Protein (NONO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN947Rb01 | Monoclonal Antibody to Non POU Domain Containing Octamer Binding Protein (NONO) | WB; IHC; ICC; IP. |
| PAN947Rb01 | Polyclonal Antibody to Non POU Domain Containing Octamer Binding Protein (NONO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN947Rb01 | CLIA Kit for Non POU Domain Containing Octamer Binding Protein (NONO) | CLIA assay for Antigen Detection |
| ELN947Rb01 | ELISA Kit for Non POU Domain Containing Octamer Binding Protein (NONO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN947Mo01 | Recombinant Non POU Domain Containing Octamer Binding Protein (NONO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN947Mo01 | Monoclonal Antibody to Non POU Domain Containing Octamer Binding Protein (NONO) | WB; IHC; ICC; IP. |
| PAN947Mo01 | Polyclonal Antibody to Non POU Domain Containing Octamer Binding Protein (NONO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN947Mo01 | CLIA Kit for Non POU Domain Containing Octamer Binding Protein (NONO) | CLIA assay for Antigen Detection |
| ELN947Mo01 | ELISA Kit for Non POU Domain Containing Octamer Binding Protein (NONO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6."
Nucleic Acids Res. 21:4085-4092(1993) [PubMed] [Europe PMC] [Abstract]
"Loss of expression of a 55 kDa nuclear protein (nmt55) in estrogen receptor-negative human breast cancer."
Diagn. Mol. Pathol. 6:209-221(1997) [PubMed] [Europe PMC] [Abstract]
"AFX1 and p54nrb: fine mapping, genomic structure, and exclusion as candidate genes of X-linked dystonia parkinsonism."
Hum. Genet. 100:569-572(1997) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Purification and characterization of a DNA-binding heterodimer of 52 and 100 kDa from HeLa cells."
Biochem. J. 290:267-272(1993) [PubMed] [Europe PMC] [Abstract]