Phosphoinositide-3-Kinase Class 3 (PIK3C3)

Vps34; Phosphatidylinositol 3-kinase p100 subunit; Phosphatidylinositol 3-kinase catalytic subunit type 3

SPN	N937
HGNC	8974
MGI	2445019
PubMed	21283715
RGD	620899
UniProt	Q8NEB9
Wiki	PIK3C3

Phosphoinositide (PI) 3-kinases are involved in both receptor-mediated signal transduction and intracellular trafficking. In yeast, the vps34 gene product is a PI 3-kinase that mediates the active diversion of proteins from the secretory pathway to vacuoles. Mammals appear to have a family of PI 3-kinases, which also includes PIK3CG and PIK3CA. The full-length PIK3C3 cDNA encodes an 887-amino acid polypeptide that is 37% identical to yeast vps34 over its entire length. Its predicted and observed molecular mass is approximately 100 kD. PIK3C3 gene was expressed as a 3.7-kb transcript in all human tissues examined.The PIK3C3 gene does not associate with the p85 regulatory subunit but does form a complex with p150, a mammalian homolog of another protein in the yeast vps pathway.

Reference

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human VPS34 and p150 are Rab7 interacting partners."
Traffic 4:754-771(2003) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

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Cell 154:1085-1099(2013) [PubMed] [Europe PMC] [Abstract]

"Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy."
Mol. Cell. Biol. 33:3675-3688(2013) [PubMed] [Europe PMC] [Abstract]