Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd)

p110D; P110δ; Phosphoinositide-3-Kinase C; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta

SPN	N933
HGNC	8977
MGI	1098211
PubMed	24293274
RGD	1310990
UniProt	O00329
Wiki	PIK3CD

Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110-alpha, p110-beta, and p110-gamma . p110-alpha and p110-beta interact with SH2/SH3-domain-containing p85 adaptor proteins and with GTP-bound Ras.

Like p110-alpha and p110-beta, p110-delta binds p85 adaptor proteins and GTP-bound Ras. These 3 class I PI3Ks were indistinguishable at the level of p85 adaptor protein selection or recruitment to activated receptor complexes. However, unlike p110-alpha, p110-delta does not phosphorylate p85, but instead has an autophosphorylation activity.

Reference

"P110delta, a novel phosphoinositide 3-kinase in leukocytes."
Proc. Natl. Acad. Sci. U.S.A. 94:4330-4335(1997) [PubMed] [Europe PMC] [Abstract]

"p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes."
J. Biol. Chem. 272:19236-19241(1997) [PubMed] [Europe PMC] [Abstract]

"p37delta is a new isoform of PI3K p110delta that increases cell proliferation and is overexpressed in tumors."
Oncogene 31:3277-3286(2012) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Autophosphorylation of p110 delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo."
EMBO J. 18:1292-1302(1999) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans."
Blood 115:2203-2213(2010) [PubMed] [Europe PMC] [Abstract]

"PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?"
Nat. Rev. Immunol. 7:191-201(2007) [PubMed] [Europe PMC] [Abstract]

"Phosphoinositide 3-kinase delta (PI3Kdelta) in leukocyte signaling and function."
Cell. Signal. 23:603-608(2011) [PubMed] [Europe PMC] [Abstract]

"Phosphoinositide 3-kinase delta gene mutation predisposes to respiratory infection and airway damage."
Science 342:866-871(2013) [PubMed] [Europe PMC] [Abstract]