AF4/FMR2 Family, Member 1 (AFF1)

AF-4; AF4; AF4-MLL; MLL/AF4; MLLT2; PBM1; Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To 2; Pre-B-Cell Monocytic Leukemia Partner 1

SPN	N891
HGNC	7135
MGI	1100819
PubMed	24367103
RGD	1307940
UniProt	P51825
Wiki	AFF1

The sequence of the complete open reading frame for this fusion transcript revealed that the MLL protein is homologous with DNA methyltransferase, the Drosophila trithorax gene product, and the 'AT-hook' motif of high mobility group proteins. An alternative splice that deletes the AT-hook region of MLL was identified. AF4 is a serine- and proline-rich putative transcription factor with a glutamine-rich carboxyl terminus.

The composition of the complete MLL-AF4 fusion product argues that it may act through either a gain-of-function or a dominant-negative mechanism in leukemogenesis. This gene is also symbolized MLLT2

Reference

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"Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding."
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