HLA-B Associated Transcript 3 (BAT3)

BAG6; Protein G3; Protein Scythe; BCL2-associated athanogene 6; BAG family molecular chaperone regulator 6; Large proline-rich protein BAG6

SPN	N812
HGNC	13919
MGI	1919439
PubMed	2156268
RGD	71064
UniProt	P46379
Wiki	BAT3

BAT3 contains an N-terminal ubiquitin-like domain, and both BAT2 and BAT3 are rich in proline and include short tracts of polyproline, polyglycine, and charged amino acids.The presence of additional genes was suggested by a large cluster of CpG islands. With cosmid probes, 5 distinct transcripts, including BAT3, were detected in RNA samples from a variety of cell lines, and the corresponding cDNA clones were isolated.BAT3 formed a complex with p300 (EP300), and an increased amount of BAT3 enhanced recruitment of p53 to p300 and facilitated subsequent p53 acetylation. In contrast, Bat3-depleted cells showed reduced p53-p300 complex formation and decreased p53 acetylation. Thymocytes from Bat3-deficient mice exhibited reduced p53-mediated induction of Puma and p21 and were resistant to DNA damage-induced apoptosis in vivo.

Reference

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"BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression."
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"E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substrates."
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"Bat3 promotes the membrane integration of tail-anchored proteins."
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J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6."
Mol. Cell 55:227-237(2014) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the N-terminal ubiquitin-like domain in the human BAT3 protein."
Submitted (JUL-2005) to the PDB data bank