NANOG Homeobox Protein (NANOG)

Homeobox transcription factor Nanog

SPN	N767
HGNC	20857
MGI	1919200
PubMed	23892456
RGD	1303178
UniProt	Q9H9S0
Wiki	NANOG

NANOG is a transcription factor critically involved with self-renewal of undifferentiated embryonic stem cells. Human NANOG protein is a 305 amino acid protein with a conserved homeodomain motif that is localized to the nuclear component of cells. The homeodomain region facilitates DNA binding. There are N-terminal, homeodomain, and C-terminal regions in human NANOG protein. Like murine NANOG, N-terminal region of human NANOG is rich in Ser, Thr and Pro residues and C-terminus contains W repeats. The homeodomain in hNANOG ranges from residues 95 to 155. NANOG is a gene expressed in embryonic stem cells (ESCs) and is thought to be a key factor in maintaining pluripotency. NANOG is thought to function in concert with other factors such as POU5F1 and SOX2 to establish ESC identity.

Reference

"The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells."
Cell 113:631-642(2003) [PubMed] [Europe PMC] [Abstract]

"Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma."
Stem Cells 22:169-179(2004) [PubMed] [Europe PMC] [Abstract]

"Identification and functional characterization of an alternative splice variant within the fourth exon of human nanog."
Exp. Mol. Med. 37:601-607(2005) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells."
Cell 113:643-655(2003) [PubMed] [Europe PMC] [Abstract]

"Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human."
Dev. Dyn. 230:187-198(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of a putative transactivation domain in human Nanog."
Exp. Mol. Med. 37:250-254(2005) [PubMed] [Europe PMC] [Abstract]

"Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours."
Histopathology 47:48-56(2005) [PubMed] [Europe PMC] [Abstract]

"Pluripotential competence of cells associated with Nanog activity."
Mech. Dev. 122:67-79(2005) [PubMed] [Europe PMC] [Abstract]

"Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages."
Stem Cells 23:1035-1043(2005) [PubMed] [Europe PMC] [Abstract]

"Solution structure of human stem cell transcription factor NANOG."
Submitted (MAR-2010) to the PDB data bank

"Eleven daughters of NANOG."
Genomics 84:229-238(2004) [PubMed] [Europe PMC] [Abstract]