SATB Homeobox Protein 1 (SATB1)

DNA-binding protein SATB1; Special AT-Rich Sequence Binding Protein 1(Binds To Nuclear Matrix/Scaffold-Associating DNA's)

SPN	N753
HGNC	10541
MGI	105084
PubMed	23791645
RGD	1305561
UniProt	Q01826
Wiki	SATB1

SATB1, the global chromatin organizer and transcription factor, has emerged as a key factor integrating higher-order chromatin architecture with gene regulation. Recent studies have unraveled the role of SATB1 in organization of chromatin 'loopscape' and its dynamic nature in response to physiological stimuli. At genome-wide level, SATB1 seems to play a role in organization of the transcriptionally poised chromatin. SATB1 organizes the MHC class-I locus into distinct chromatin loops by tethering MARs to nuclear matrix at fixed distances. Silencing of SATB1 mimics the effects of IFN-γ treatment on chromatin loop architecture of the MHC class I locus and altered expression of genes within the locus. SATB1induce breast cancer tumor growth and metastasis through the altered expression of large numbers of genes.

Reference

"A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition."
Cell 70:631-645(1992) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"An atypical homeodomain in SATB1 promotes specific recognition of the key structural element in a matrix attachment region."
J. Biol. Chem. 272:11463-11470(1997) [PubMed] [Europe PMC] [Abstract]

"The genomic sequences bound to special AT-rich sequence-binding protein 1 (SATB1) in vivo in Jurkat T cells are tightly associated with the nuclear matrix at the bases of the chromatin loops."
J. Cell Biol. 141:335-348(1998) [PubMed] [Europe PMC] [Abstract]

"The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation."
DNA Cell Biol. 18:805-817(1999) [PubMed] [Europe PMC] [Abstract]

"The fate of the nuclear matrix-associated-region-binding protein SATB1 during apoptosis."
Cell Death Differ. 7:425-438(2000) [PubMed] [Europe PMC] [Abstract]

"SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis."
Mol. Cell. Biol. 21:5591-5604(2001) [PubMed] [Europe PMC] [Abstract]

"The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11."
Genomics 79:809-817(2002) [PubMed] [Europe PMC] [Abstract]

"SATB1 targets chromatin remodelling to regulate genes over long distances."
Nature 419:641-645(2002) [PubMed] [Europe PMC] [Abstract]

"SATB1 makes a complex with p300 and represses gp91(phox) promoter activity."
Microbiol. Immunol. 47:803-811(2003) [PubMed] [Europe PMC] [Abstract]

"Tissue-specific nuclear architecture and gene expression regulated by SATB1."
Nat. Genet. 34:42-51(2003) [PubMed] [Europe PMC] [Abstract]

"SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression."
Blood 105:3330-3339(2005) [PubMed] [Europe PMC] [Abstract]

"A nuclear targeting determinant for SATB1, a genome organizer in the T cell lineage."
Cell Cycle 4:1099-1106(2005) [PubMed] [Europe PMC] [Abstract]

"Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates."
J. Biol. Chem. 280:5004-5012(2005) [PubMed] [Europe PMC] [Abstract]

"Nuclear matrix binding regulates SATB1-mediated transcriptional repression."
J. Biol. Chem. 280:24600-24609(2005) [PubMed] [Europe PMC] [Abstract]

"Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway."
J. Cell Sci. 118:3431-3443(2005) [PubMed] [Europe PMC] [Abstract]

"Displacement of SATB1-bound histone deacetylase 1 corepressor by the human immunodeficiency virus type 1 transactivator induces expression of interleukin-2 and its receptor in T cells."
Mol. Cell. Biol. 25:1620-1633(2005) [PubMed] [Europe PMC] [Abstract]

"The behavior of SATB1, a MAR-binding protein, in response to apoptosis stimulation."
Cell Biol. Int. 30:244-247(2006) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo."
Mol. Cell 22:231-243(2006) [PubMed] [Europe PMC] [Abstract]

"SATB1-binding sequences and Alu-like motifs define a unique chromatin context in the vicinity of human immunodeficiency virus type 1 integration sites."
J. Virol. 81:5617-5627(2007) [PubMed] [Europe PMC] [Abstract]

"Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus."
Nat. Cell Biol. 9:45-56(2007) [PubMed] [Europe PMC] [Abstract]

"Cellular homeoproteins, SATB1 and CDP, bind to the unique region between the human cytomegalovirus UL127 and major immediate-early genes."
Virology 366:117-125(2007) [PubMed] [Europe PMC] [Abstract]

"SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage."
J. Biol. Chem. 283:18124-18134(2008) [PubMed] [Europe PMC] [Abstract]

"SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis."
Nature 452:187-193(2008) [PubMed] [Europe PMC] [Abstract]

"PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATB1."
Nucleic Acids Res. 36:2107-2122(2008) [PubMed] [Europe PMC] [Abstract]

"SATB1 regulates beta-like globin genes through matrix related nuclear relocation of the cluster."
Biochem. Biophys. Res. Commun. 383:11-15(2009) [PubMed] [Europe PMC] [Abstract]

"SATB1 binds an intronic MAR sequence in human PI3kgamma in vitro."
Mol. Biol. Rep. 37:1461-1465(2010) [PubMed] [Europe PMC] [Abstract]

"Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1."
Mol. Cell. Biol. 29:1321-1337(2009) [PubMed] [Europe PMC] [Abstract]

"Inter-MAR association contributes to transcriptionally active looping events in human beta-globin gene cluster."
PLoS ONE 4:E4629-E4629(2009) [PubMed] [Europe PMC] [Abstract]

"Solution structure and DNA-binding mode of the matrix attachment region-binding domain of the transcription factor SATB1 that regulates the T-cell maturation."
J. Biol. Chem. 281:5319-5327(2006) [PubMed] [Europe PMC] [Abstract]

"Structural basis for recognition of the matrix attachment region of DNA by transcription factor SATB1."
Nucleic Acids Res. 35:5073-5084(2007) [PubMed] [Europe PMC] [Abstract]