Four And A Half LIM Domains Protein 1 (FHL1)

FHL1B; KYO-T; SLIM1; XMPMA; FLH1A; LIM Protein SLIMMER; Skeletal muscle LIM-protein 1

SPN	N673
HGNC	3702
MGI	1298387
PubMed	18274675
RGD	2615
UniProt	Q13642
Wiki	FHL1

FHL1 encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.
The predicted 280-amino acid protein contains 4 LIM domains and a novel single zinc finger domain in the N-terminal region. By Northern blot analysis, SLIM1 is expressed as a 2.3-kb mRNA in human masseter muscle.

Reference

"Slim defines a novel family of LIM-proteins expressed in skeletal muscle."
Biochem. Biophys. Res. Commun. 225:632-638(1996) [PubMed] [Europe PMC] [Abstract]

"Chromosomal mapping, tissue distribution and cDNA sequence of four-and-a-half LIM domain protein 1 (FHL1)."
Gene 216:163-170(1998) [PubMed] [Europe PMC] [Abstract]

"Genomic structure, tissue expression and chromosomal location of the LIM-only gene, SLIM1."
Gene 232:203-207(1999) [PubMed] [Europe PMC] [Abstract]

"Characterization of a brain-specific nuclear LIM domain protein (FHL1B) which is an alternatively spliced variant of FHL1."
Gene 237:253-263(1999) [PubMed] [Europe PMC] [Abstract]

"Characterization of two isoforms of the skeletal muscle LIM protein 1, SLIM1. Localization of SLIM1 at focal adhesions and the isoform slimmer in the nucleus of myoblasts and cytoplasm of myotubes suggests distinct roles in the cytoskeleton and in nuclear-cytoplasmic communication."
J. Biol. Chem. 274:27083-27091(1999) [PubMed] [Europe PMC] [Abstract]

"Characterization of tissue-specific LIM domain protein (FHL1C) which is an alternatively spliced isoform of a human LIM-only protein (FHL1)."
J. Cell. Biochem. 82:1-10(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The developmental regulation of a novel muscle LIM-protein."
Biochem. Biophys. Res. Commun. 212:840-846(1995) [PubMed] [Europe PMC] [Abstract]

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Solution structure of LIM domains from human four and a half LIM domains 1."
Submitted (SEP-2007) to the PDB data bank

"An X-linked myopathy with postural muscle atrophy and generalized hypertrophy, termed XMPMA, is caused by mutations in FHL1."
Am. J. Hum. Genet. 82:88-99(2008) [PubMed] [Europe PMC] [Abstract]

"X-linked dominant scapuloperoneal myopathy is due to a mutation in the gene encoding four-and-a-half-LIM protein 1."
Am. J. Hum. Genet. 82:208-213(2008) [PubMed] [Europe PMC] [Abstract]

"Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy."
J. Clin. Invest. 118:904-912(2008) [PubMed] [Europe PMC] [Abstract]