NLR Family, Pyrin Domain Containing Protein 3 (NLRP3)
AVP; AGTAVPRL; AII; AII/AVP; C1orf7; CIAS1; CLR1.1; FCAS; FCU; MWS; NALP3; PYPAF1; Cryopyrin; Cold Induced Autoinflammatory Syndrome 1; Caterpiller-Like Receptor 1.1
NLRP3 encodes a pyrin-like protein which contains a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with apoptosis-associated speck-like protein containing a CARD. Proteins which contain the caspase recruitment domain, CARD, have been shown to be involved in inflammation and immune response. This protein may function as an activator of NF-κB signaling.
The protein may play a role in the regulation of inflammation and apoptosis. Mutations in this gene have been associated with a spectrum of dominantly inherited autoinflammatory diseases called cryopyrin-associated periodic syndrome (CAPS). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEN623Hu | ELISA Kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| KCN623Hu | CLIA kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | N623Mu01 | Recombinant NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IP. |
| PN623Mu01 | Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEN623Ra | ELISA Kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) | CLIA assay for Antigen Detection |
Reference
"Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome."
Nat. Genet. 29:301-305(2001) [PubMed] [Europe PMC] [Abstract]
"Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis."
Arthritis Rheum. 46:2445-2452(2002) [PubMed] [Europe PMC] [Abstract]
"PYPAF1: a PYRIN-containing APAF1-like protein that assembles with ASC and activates NF-kB."
J. Biol. Chem. 277:11570-11575(2002) [PubMed] [Europe PMC] [Abstract]
"CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties."
J. Immunol. 171:6329-6333(2003) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
"NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder."
Immunity 20:319-325(2004) [PubMed] [Europe PMC] [Abstract]
"The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing."
Cell Death Differ. 14:1457-1466(2007) [PubMed] [Europe PMC] [Abstract]
"Inflammasome components NALP 1 and 3 Show distinct but separate Expression profiles in human tissues suggesting a site-specific role in the inflammatory response."
J. Histochem. Cytochem. 55:443-452(2007) [PubMed] [Europe PMC] [Abstract]
"Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell death."
J. Bone Miner. Res. 23:30-40(2008) [PubMed] [Europe PMC] [Abstract]
"Novel role of PKR in inflammasome activation and HMGB1 release."
Nature 488:670-674(2012) [PubMed] [Europe PMC] [Abstract]
"Selective inhibition of the NLRP3 inflammasome by targeting to promyelocytic leukemia protein in mouse and human."
Blood 121:3185-3194(2013) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of NALP3 protein pyrin domain (PYD) and its implications in inflammasome assembly."
J. Biol. Chem. 286:39528-39536(2011) [PubMed] [Europe PMC] [Abstract]
"New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes."
Am. J. Hum. Genet. 70:1498-1506(2002) [PubMed] [Europe PMC] [Abstract]
"Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes."
Am. J. Hum. Genet. 71:198-203(2002) [PubMed] [Europe PMC] [Abstract]
"De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases."
Arthritis Rheum. 46:3340-3348(2002) [PubMed] [Europe PMC] [Abstract]
"Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P."
Hum. Genet. 112:209-216(2003) [PubMed] [Europe PMC] [Abstract]
"Variant chronic infantile neurologic, cutaneous, articular syndrome due to a mutation within the leucine-rich repeat domain of CIAS1."
Arthritis Rheum. 50:2719-2720(2004) [PubMed] [Europe PMC] [Abstract]
"Clinical and genetic heterogeneity among Spanish patients with recurrent autoinflammatory syndromes associated with the CIAS1/PYPAF1/NALP3 gene."
Arthritis Rheum. 50:4045-4050(2004) [PubMed] [Europe PMC] [Abstract]
"Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU."
Blood 103:2809-2815(2004) [PubMed] [Europe PMC] [Abstract]
"A novel CIAS1 mutation and plasma/cerebrospinal fluid cytokine profile in a German patient with neonatal-onset multisystem inflammatory disease responsive to methotrexate therapy."
Pediatrics 114:E124-E127(2004) [PubMed] [Europe PMC] [Abstract]
"A novel missense mutation in CIAS1 encoding the pyrin-like protein, cryopyrin, causes familial cold autoinflammatory syndrome in a family of Ethiopian origin."
Int. Arch. Allergy Immunol. 143:190-193(2007) [PubMed] [Europe PMC] [Abstract]