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Slingshot Homolog 2 (SSH2)

SSH2L; SSH-like protein 2; Protein phosphatase Slingshot homolog 2

Two of the human proteins, SSH1L and SSH2, were enzymatically active when reacted with an artificial substrate, p-nitrophenyl phosphate. SSH3 did not exhibit activity toward p-nitrophenyl phosphate, and its expression did not reduce the level of P-cofilin in COS-7 cells. In mammalian cells, SSH1L and SSH2 suppressed LIMK1-induced actin reorganization. Furthermore, ssh, SSH1L, and SSH2 dephosphorylated P-cofilin in cultured cells and in cell-free assays. SSH1 encodes 3 isoforms, SSH1L, SSH1S, and SSH1B, and SSH2 encodes 2 isoforms, SSH2 and SSH2B. The SSH3 protein has 471 amino acids. Besides the catalytic domain, 2 other domains are conserved between Drosophila ssh and the human SSHs (domains A and B) and are unique to the SSH family.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN576Hu01 Recombinant Slingshot Homolog 2 (SSH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAN576Hu01 Monoclonal Antibody to Slingshot Homolog 2 (SSH2) WB; IHC; ICC; IP.
PAN576Hu01 Polyclonal Antibody to Slingshot Homolog 2 (SSH2) WB; IHC; ICC; IF.
Assay Kits CLN576Hu01 CLIA Kit for Slingshot Homolog 2 (SSH2) CLIA assay for Antigen Detection
ELN576Hu01 ELISA Kit for Slingshot Homolog 2 (SSH2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN576Mu01 Recombinant Slingshot Homolog 2 (SSH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAN576Mu01 Monoclonal Antibody to Slingshot Homolog 2 (SSH2) WB; IHC; ICC; IP.
PAN576Mu01 Polyclonal Antibody to Slingshot Homolog 2 (SSH2) WB; IHC; ICC; IF.
Assay Kits CLN576Mu01 CLIA Kit for Slingshot Homolog 2 (SSH2) CLIA assay for Antigen Detection
ELN576Mu01 ELISA Kit for Slingshot Homolog 2 (SSH2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN576Ra01 Recombinant Slingshot Homolog 2 (SSH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAN576Ra01 Monoclonal Antibody to Slingshot Homolog 2 (SSH2) WB; IHC; ICC; IP.
PAN576Ra01 Polyclonal Antibody to Slingshot Homolog 2 (SSH2) WB; IHC; ICC; IF.
Assay Kits CLN576Ra01 CLIA Kit for Slingshot Homolog 2 (SSH2) CLIA assay for Antigen Detection
ELN576Ra01 ELISA Kit for Slingshot Homolog 2 (SSH2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN576Ca01 Recombinant Slingshot Homolog 2 (SSH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAN576Ca01 Monoclonal Antibody to Slingshot Homolog 2 (SSH2) WB; IHC; ICC; IP.
PAN576Ca01 Polyclonal Antibody to Slingshot Homolog 2 (SSH2) WB; IHC; ICC; IF.
Assay Kits CLN576Ca01 CLIA Kit for Slingshot Homolog 2 (SSH2) CLIA assay for Antigen Detection
ELN576Ca01 ELISA Kit for Slingshot Homolog 2 (SSH2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN576Po01 Recombinant Slingshot Homolog 2 (SSH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAN576Po01 Monoclonal Antibody to Slingshot Homolog 2 (SSH2) WB; IHC; ICC; IP.
PAN576Po01 Polyclonal Antibody to Slingshot Homolog 2 (SSH2) WB; IHC; ICC; IF.
Assay Kits CLN576Po01 CLIA Kit for Slingshot Homolog 2 (SSH2) CLIA assay for Antigen Detection
ELN576Po01 ELISA Kit for Slingshot Homolog 2 (SSH2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN576Bo01 Recombinant Slingshot Homolog 2 (SSH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAN576Bo01 Monoclonal Antibody to Slingshot Homolog 2 (SSH2) WB; IHC; ICC; IP.
PAN576Bo01 Polyclonal Antibody to Slingshot Homolog 2 (SSH2) WB; IHC; ICC; IF.
Assay Kits CLN576Bo01 CLIA Kit for Slingshot Homolog 2 (SSH2) CLIA assay for Antigen Detection
ELN576Bo01 ELISA Kit for Slingshot Homolog 2 (SSH2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN576Rb01 Recombinant Slingshot Homolog 2 (SSH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAN576Rb01 Monoclonal Antibody to Slingshot Homolog 2 (SSH2) WB; IHC; ICC; IP.
PAN576Rb01 Polyclonal Antibody to Slingshot Homolog 2 (SSH2) WB; IHC; ICC; IF.
Assay Kits CLN576Rb01 CLIA Kit for Slingshot Homolog 2 (SSH2) CLIA assay for Antigen Detection
ELN576Rb01 ELISA Kit for Slingshot Homolog 2 (SSH2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN576Mo01 Recombinant Slingshot Homolog 2 (SSH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAN576Mo01 Monoclonal Antibody to Slingshot Homolog 2 (SSH2) WB; IHC; ICC; IP.
PAN576Mo01 Polyclonal Antibody to Slingshot Homolog 2 (SSH2) WB; IHC; ICC; IF.
Assay Kits CLN576Mo01 CLIA Kit for Slingshot Homolog 2 (SSH2) CLIA assay for Antigen Detection
ELN576Mo01 ELISA Kit for Slingshot Homolog 2 (SSH2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin."
Cell 108:233-246(2002) [PubMed] [Europe PMC] [Abstract]

"Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin."
Genes Cells 8:811-824(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of genes expressed during myocardial development."
Chin. Med. J. 116:1329-1332(2003) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human slingshot phosphatase 2."
Proteins 68:408-412(2007) [PubMed] [Europe PMC] [Abstract]