Slingshot Homolog 1 (SSH1)

SSH1L; SSH-like protein 1; Protein phosphatase Slingshot homolog 1

SPN	N575
HGNC	30579
MGI	2686240
PubMed	22496574
RGD	1306038
UniProt	Q8WYL5
Wiki	SSH1

The ADF (actin-depolymerizing factor)/cofilin family is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo. Transcript analysis suggested that at least 6 polypeptides would be produced from these genes. SSH1 encodes 3 isoforms, SSH1L (1,049 amino acids), SSH1S (692 amino acids), and SSH1B (148 amino acids), and SSH2 encodes 2 isoforms, SSH2 (449 amino acids) and SSH2B (195 amino acids). The SSH3 protein has 471 amino acids. Besides the catalytic domain, 2 other domains are conserved between Drosophila ssh and the human SSHs and are unique to the SSH family.

Reference

"Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin."
Cell 108:233-246(2002) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin."
Genes Cells 8:811-824(2003) [PubMed] [Europe PMC] [Abstract]

"Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells."
J. Biol. Chem. 278:33450-33455(2003) [PubMed] [Europe PMC] [Abstract]

"Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin."
J. Neurosci. 23:2527-2537(2003) [PubMed] [Europe PMC] [Abstract]

"Efficient Salmonella entry requires activity cycles of host ADF and cofilin."
Cell. Microbiol. 6:459-471(2004) [PubMed] [Europe PMC] [Abstract]

"Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion."
J. Biol. Chem. 279:7193-7198(2004) [PubMed] [Europe PMC] [Abstract]

"A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia."
J. Cell Biol. 165:465-471(2004) [PubMed] [Europe PMC] [Abstract]

"Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin."
EMBO J. 24:473-486(2005) [PubMed] [Europe PMC] [Abstract]

"Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin."
J. Biol. Chem. 280:12683-12689(2005) [PubMed] [Europe PMC] [Abstract]

"Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration."
J. Cell Biol. 171:349-359(2005) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]