Leucine Rich Repeat LGI Family, Member 3 (LGI3)
LGIL4; LGI1-like protein 4; Leucine-rich glioma-inactivated protein 3
The deduced 549-amino acid protein contains a N-terminal signal peptide, a putative transmembrane region, and 1 partial and 4 complete leucine-rich repeats (LRRs). The LRRs are flanked on both sides by cysteine-rich regions, and the N-terminal cysteine-rich region contains a motif conserved in LGIs. LGI3 shares significant similarity with LGI1, LGI2, and LGI4. Semiquantitative PCR detected LGI3 expression in all tissues examined, with highest levels in brain and lung.
By in situ hybridization of adult mouse brain, Senechal et al. (2005) showed that Lgi3 was expressed at low levels in most brain regions with high levels in the facial nerve nucleus. Lgi3 was secreted in transfected 293T cells.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN569Hu01 | Recombinant Leucine Rich Repeat LGI Family, Member 3 (LGI3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN569Hu01 | Monoclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) | WB; IHC; ICC; IP. |
| PAN569Hu01 | Polyclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN569Hu01 | CLIA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) | CLIA assay for Antigen Detection |
| ELN569Hu01 | ELISA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN569Mu01 | Recombinant Leucine Rich Repeat LGI Family, Member 3 (LGI3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN569Mu01 | Monoclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) | WB; IHC; ICC; IP. |
| PAN569Mu01 | Polyclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN569Mu01 | CLIA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) | CLIA assay for Antigen Detection |
| ELN569Mu01 | ELISA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN569Ra01 | Recombinant Leucine Rich Repeat LGI Family, Member 3 (LGI3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN569Ra01 | Monoclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) | WB; IHC; ICC; IP. |
| PAN569Ra01 | Polyclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN569Ra01 | CLIA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) | CLIA assay for Antigen Detection |
| ELN569Ra01 | ELISA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN569Ca01 | Recombinant Leucine Rich Repeat LGI Family, Member 3 (LGI3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN569Ca01 | Monoclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) | WB; IHC; ICC; IP. |
| PAN569Ca01 | Polyclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN569Ca01 | CLIA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) | CLIA assay for Antigen Detection |
| ELN569Ca01 | ELISA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN569Po01 | Recombinant Leucine Rich Repeat LGI Family, Member 3 (LGI3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN569Po01 | Monoclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) | WB; IHC; ICC; IP. |
| PAN569Po01 | Polyclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN569Po01 | CLIA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) | CLIA assay for Antigen Detection |
| ELN569Po01 | ELISA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN569Bo01 | Recombinant Leucine Rich Repeat LGI Family, Member 3 (LGI3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN569Bo01 | Monoclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) | WB; IHC; ICC; IP. |
| PAN569Bo01 | Polyclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN569Bo01 | CLIA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) | CLIA assay for Antigen Detection |
| ELN569Bo01 | ELISA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN569Rb01 | Recombinant Leucine Rich Repeat LGI Family, Member 3 (LGI3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN569Rb01 | Monoclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) | WB; IHC; ICC; IP. |
| PAN569Rb01 | Polyclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN569Rb01 | CLIA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) | CLIA assay for Antigen Detection |
| ELN569Rb01 | ELISA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN569Mo01 | Recombinant Leucine Rich Repeat LGI Family, Member 3 (LGI3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN569Mo01 | Monoclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) | WB; IHC; ICC; IP. |
| PAN569Mo01 | Polyclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN569Mo01 | CLIA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) | CLIA assay for Antigen Detection |
| ELN569Mo01 | ELISA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins."
FEBS Lett. 519:71-76(2002) [PubMed] [Europe PMC] [Abstract]
"A common protein interaction domain links two recently identified epilepsy genes."
Hum. Mol. Genet. 11:1757-1762(2002) [PubMed] [Europe PMC] [Abstract]
"The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders."
Trends Biochem. Sci. 27:441-444(2002) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]