Pescadillo Homolog 1 (PES1)

SPN	N562
HGNC	8848
MGI	1890613
PubMed	22820289
UniProt	O00541
Wiki	PES1

PES1 is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product. The gene plays a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression.The deduced 588-amino acid PES1 protein is 74% identical to the zebrafish sequence. The authors noted the presence of a highly acidic region at the C terminus and that the protein has an alpha-helix structure. Immunoblot analysis showed that PES1 is expressed as an unmodified 72-kD protein and a SUMO1-modified 92-kD protein. In situ hybridization analysis revealed wide and high expression of Pes1 in embryonic mouse brain and spinal cord. Pes1 expression was upregulated in malignant, late-passage mouse astrocytes.

Reference

"Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development."
Genes Dev. 10:3141-3155(1996) [PubMed] [Europe PMC] [Abstract]

"A genome annotation-driven approach to cloning the human ORFeome."
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Pescadillo, a novel cell cycle regulatory protein abnormally expressed in malignant cells."
J. Biol. Chem. 276:6656-6665(2001) [PubMed] [Europe PMC] [Abstract]

"Yeast Pescadillo is required for multiple activities during 60S ribosomal subunit synthesis."
RNA 8:626-636(2002) [PubMed] [Europe PMC] [Abstract]

Erratum
RNA 8:851-851(2002)

"Functional proteomic analysis of human nucleolus."
Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]

"Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation."
J. Cell Biol. 170:367-378(2005) [PubMed] [Europe PMC] [Abstract]

"Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex."
Nucleic Acids Res. 34:3030-3043(2006) [PubMed] [Europe PMC] [Abstract]

"Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit."
Mol. Cell. Biol. 27:3682-3694(2007) [PubMed] [Europe PMC] [Abstract]

"The BRCT domain of mammalian Pes1 is crucial for nucleolar localization and rRNA processing."
Nucleic Acids Res. 35:789-800(2007) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the BRCT domain from human pescadillo homolog 1."
Submitted (OCT-2007) to the PDB data bank