A Disintegrin And Metalloprotease 28 (ADAM28)

ADAM23; MDCL; eMDCII; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L; Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II

SPN	N530
HGNC	206
MGI	105988
PubMed	23010875
RGD	727820
UniProt	Q9UKQ2
Wiki	ADAM28

ADAM28 encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein.

Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially in spleen.

Reference

"MDC-L, a novel metalloprotease disintegrin cysteine-rich protein family member expressed by human lymphocytes."
J. Biol. Chem. 274:29251-29259(1999) [PubMed] [Europe PMC] [Abstract]

"Identification, sequence analysis and expression of transcripts encoding a putative metalloproteinase, eMDC II, in human and macaque epididymis."
Mol. Hum. Reprod. 5:1127-1134(1999) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma."
Hum. Mutat. 32:E2148-E2175(2011) [PubMed] [Europe PMC] [Abstract]