Nucleotide Binding Oligomerization Domain Containing Protein 2 (NOD2)

CD; ACUG; BLAU; CARD15; CLR16.3; IBD1; NLRC2; NOD2B; PSORAS1; Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1

SPN	N437
HGNC	5331
MGI	2429397
PubMed	11385576
RGD	1306368
UniProt	Q9HC29
Wiki	NOD2

NOD2 is a protein, also known as the caspase recruitment domain family, member 15 (CARD15), which plays an important role in the immune system. It is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants and recognizes molecules containing the specific structure called muramyl dipeptide (MDP) that is found in certain bacteria. This gene is a member of the NOD1/Apaf-1 family and encodes a protein with two caspase recruitment domains (CARDs) and eleven leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response by recognizing the bacterial molecules which possess the muramyl dipeptide (MDP) moiety and activating the NF-κB protein.

Reference

"Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB."
J. Biol. Chem. 276:4812-4818(2001) [PubMed] [Europe PMC] [Abstract]

"Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease."
Nature 411:599-603(2001) [PubMed] [Europe PMC] [Abstract]

"NOD2-C2 - a novel NOD2 isoform activating NF-kappaB in a muramyl dipeptide-independent manner."
BMC Res. Notes 3:224-224(2010) [PubMed] [Europe PMC] [Abstract]

"A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling."
J. Biol. Chem. 280:40301-40309(2005) [PubMed] [Europe PMC] [Abstract]

"ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways."
Curr. Biol. 19:1255-1263(2009) [PubMed] [Europe PMC] [Abstract]

"Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1."
Inflamm. Bowel Dis. 18:603-612(2012) [PubMed] [Europe PMC] [Abstract]

"Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components."
J. Biol. Chem. 287:39800-39811(2012) [PubMed] [Europe PMC] [Abstract]

"TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3."
EMBO J. 32:566-582(2013) [PubMed] [Europe PMC] [Abstract]

"A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses."
FEBS Lett. 587:2137-2142(2013) [PubMed] [Europe PMC] [Abstract]

"OTULIN restricts Met1-linked ubiquitination to control innate immune signaling."
Mol. Cell 50:818-830(2013) [PubMed] [Europe PMC] [Abstract]

"Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain."
FEBS Lett. 588:2830-2836(2014) [PubMed] [Europe PMC] [Abstract]

"Blau syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and helical domain 1 as signalling regulators."
FEBS Lett. 588:3382-3389(2014) [PubMed] [Europe PMC] [Abstract]

"The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease."
J. Biol. Chem. 289:18987-18998(2014) [PubMed] [Europe PMC] [Abstract]

"CARD15 mutations in Blau syndrome."
Nat. Genet. 29:19-20(2001) [PubMed] [Europe PMC] [Abstract]

"Crohn disease: frequency and nature of CARD15 mutations in Ashkenazi and Sephardi/Oriental Jewish families."
Am. J. Hum. Genet. 74:623-636(2004) [PubMed] [Europe PMC] [Abstract]

"Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome."
Blood 105:1195-1197(2005) [PubMed] [Europe PMC] [Abstract]

"A new CARD15 mutation in Blau syndrome."
Eur. J. Hum. Genet. 13:742-747(2005) [PubMed] [Europe PMC] [Abstract]

"Eight novel CARD15 variants detected by DNA sequence analysis of the CARD15 gene in 111 patients with inflammatory bowel disease."
Immunogenetics 58:99-106(2006) [PubMed] [Europe PMC] [Abstract]

"NOD2-associated pediatric granulomatous arthritis, an expanding phenotype: study of an international registry and a national cohort in Spain."
Arthritis Rheum. 60:1797-1803(2009) [PubMed] [Europe PMC] [Abstract]

"Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis."
Arthritis Rheum. 60:242-250(2009) [PubMed] [Europe PMC] [Abstract]

"Cardiac infiltration in early-onset sarcoidosis associated with a novel heterozygous mutation, G481D, in CARD15."
Rheumatology 48:706-707(2009) [PubMed] [Europe PMC] [Abstract]

"A novel mutation in the NOD2 gene associated with Blau syndrome: a Norwegian family with four affected members."
Scand. J. Rheumatol. 38:190-197(2009) [PubMed] [Europe PMC] [Abstract]

"Sporadic Blau syndrome with onset of widespread granulomatous dermatitis in the newborn period."
Pediatr. Dermatol. 27:69-73(2010) [PubMed] [Europe PMC] [Abstract]

"A new mutation in blau syndrome."
Case Rep. Rheumatol. 2015:463959-463959(2015) [PubMed] [Europe PMC] [Abstract]

"Somatic NOD2 mosaicism in Blau syndrome."
J. Allergy Clin. Immunol. 0:0-0(2015) [PubMed] [Europe PMC] [Abstract]