NODAL Modulator 1 (NOMO1)

Nomo; PM5

SPN	N421
HGNC	30060
MGI	2385850
PubMed	22832245
RGD	1305240
UniProt	Q15155
Wiki	NOMO1

NOMO1 encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE).Templeton et al. (1992) cloned NOMO1, which they designated PM5. Northern blot analysis detected a 4.0-kb transcript in both normal and malignant colorectal tissues.

Reference

"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of a novel human cDNA that has DNA similarity to the conserved region of the collagenase gene family."
Genomics 12:175-176(1992) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum."
Nat. Genet. 25:223-227(2000) [PubMed] [Europe PMC] [Abstract]

"Identification of novel polymorphisms in the pM5 and MRP1 (ABCC1) genes at locus 16p13.1 and exclusion of both genes as responsible for pseudoxanthoma elasticum."
Hum. Mutat. 17:74-75(2001) [PubMed] [Europe PMC] [Abstract]