Sprouty Homolog 1 (SPRY1)

Antagonist Of FGF Signaling

SPN	N378
HGNC	11269
MGI	1345139
PubMed	20459789
RGD	1309293
UniProt	O43609
Wiki	SPRY1

Spry mutations in Drosophila cause excessive branching. The spry protein is an antagonist of fibroblast growth factor (FGF) signaling that patterns apical branching of the Drosophila airways. In wildtype embryos, the Branchless FGF protein induces secondary branching by activating the Breathless FGF receptor near the tips of growing primary branches.

A partial sequence of the human SPRY1 gene was identified.mouse Spry1 transfected into COS-1 cells was expressed as a cytosolic protein. Upon EGF stimulation, Spry1 translocated to membrane ruffles. Deletion analysis of human SPRY2 identified the translocation domain as a highly conserved 105-amino acid C-terminal domain.

Reference

"Identification and expression analysis of a novel splice variant of human Sprouty1 gene."
Int. J. Mol. Med. 12:783-787(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways."
Cell 92:253-263(1998) [PubMed] [Europe PMC] [Abstract]

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]