WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2)

AIP2; WWp2-like; Atrophin-1-interacting protein 2; NEDD4-like E3 ubiquitin-protein ligase WWP2

SPN	N300
HGNC	16804
MGI	1914144
PubMed	19997087
RGD	1310091
UniProt	O00308
Wiki	WWP2

WWP2 encodes a member of the NEDD4-like protein family. The family of proteins is known to possess ubiquitin-protein ligase activity. The encoded protein contains 4 tandem WW domains. The WW domain is a protein motif consisting of 35 to 40 amino acids and is characterized by 4 conserved aromatic residues. The WW domain may mediate specific protein-protein interactions. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.The deduced 870-amino acid protein has a calculated molecular mass of 98.7 kD and shares 96% identity with human WWP2. Northern blot analysis detected 2 Wwp2 transcripts, with highest expression in testis, followed by spleen, kidney, and liver.

Reference

"Identification of novel human WW domain-containing proteins by cloning of ligand targets."
J. Biol. Chem. 272:14611-14616(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins."
Mol. Cell. Neurosci. 11:149-160(1998) [PubMed] [Europe PMC] [Abstract]

"Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel."
Am. J. Physiol. 283:F431-F436(2002) [PubMed] [Europe PMC] [Abstract]

"Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases."
Biochemistry 41:14299-14305(2002) [PubMed] [Europe PMC] [Abstract]

"N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein."
J. Biol. Chem. 277:9307-9317(2002) [PubMed] [Europe PMC] [Abstract]

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

"Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain."
Cell 130:651-662(2007) [PubMed] [Europe PMC] [Abstract]

"WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells."
Cell Res. 19:561-573(2009) [PubMed] [Europe PMC] [Abstract]

"Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins."
EMBO Rep. 10:501-507(2009) [PubMed] [Europe PMC] [Abstract]

"The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination."
Mol. Cell. Biol. 29:5348-5356(2009) [PubMed] [Europe PMC] [Abstract]

"Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways."
Mol. Cancer Res. 8:1388-1398(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1."
EMBO J. 30:2675-2689(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]