Programmed Cell Death Protein 5 (PDCD5)

TFAR19; TFAR19 Novel Apoptosis-Related; TF1 Cell Apoptosis-Related Gene 19

SPN	N282
HGNC	8764
MGI	1913538
PubMed	22359193
RGD	1310561
UniProt	O14737
Wiki	PDCD5

PDCD5 encodes a protein expressed in tumor cells during apoptosis independent of the apoptosis-inducing stimuli. Prior to apoptosis induction, this gene product is distributed in both the nucleus and cytoplasm. Once apoptosis is induced, the level of this protein increases and by relocation from the cytoplasm, it accumulates in the nucleus. Although its exact function is not defined, this protein is thought to play an early and universal role in apoptosis.This TFAR19 gene encodes a protein of 125 amino acids, with an ATG initiation codon at nucleotides 25-27. It contains a cAMP- and cGMP-dependent protein kinase phosphorylation site, multiple protein kinase C phosphorylation sites, and a casein kinase II phosphorylation site. It shares significant homology to the corresponding proteins of species ranging from yeast to mice.

Reference

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Submitted (NOV-2005) to the PDB data bank

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