Programmed Cell Death Protein 4 (PDCD4)

H731; Neoplastic Transformation Inhibitor; Nuclear antigen H731-like; Protein 197/15a

SPN	N279
HGNC	8763
MGI	107490
PubMed	23758151
RGD	620816
UniProt	Q53EL6
Wiki	PDCD4

PDCD4 encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.The deduced 458-amino acid protein has a calculated molecular mass of 50.6 kD. PDCD4 is an acidic protein with characteristics of a nuclear nonhistone protein. It contains 2 overlapping GxGxxG nucleotide-binding motifs, which are characteristic of protein kinases, but it does not have a kinase catalytic domain. PDCD4 also has several putative serine and threonine phosphorylation sites. Northern blot analysis detected transcripts of about 2.7 and 3.8 kb in HeLa cell total RNA.

Reference

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Submitted (APR-2007) to the PDB data bank

"PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains."
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