Notch Homolog 4 (NOTCH4)
INT3; Neurogenic locus notch homolog protein 4
NOTCH4 encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types.
This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN238Hu01 | Recombinant Notch Homolog 4 (NOTCH4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN238Hu01 | Monoclonal Antibody to Notch Homolog 4 (NOTCH4) | WB; IHC; ICC; IP. |
| PAN238Hu01 | Polyclonal Antibody to Notch Homolog 4 (NOTCH4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN238Hu01 | CLIA Kit for Notch Homolog 4 (NOTCH4) | CLIA assay for Antigen Detection |
| ELN238Hu01 | ELISA Kit for Notch Homolog 4 (NOTCH4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN238Mu01 | Recombinant Notch Homolog 4 (NOTCH4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN238Mu01 | Monoclonal Antibody to Notch Homolog 4 (NOTCH4) | WB; IHC; ICC; IP. |
| PAN238Mu01 | Polyclonal Antibody to Notch Homolog 4 (NOTCH4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN238Mu01 | CLIA Kit for Notch Homolog 4 (NOTCH4) | CLIA assay for Antigen Detection |
| ELN238Mu01 | ELISA Kit for Notch Homolog 4 (NOTCH4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN238Ra01 | Recombinant Notch Homolog 4 (NOTCH4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN238Ra01 | Monoclonal Antibody to Notch Homolog 4 (NOTCH4) | WB; IHC; ICC; IP. |
| PAN238Ra01 | Polyclonal Antibody to Notch Homolog 4 (NOTCH4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN238Ra01 | CLIA Kit for Notch Homolog 4 (NOTCH4) | CLIA assay for Antigen Detection |
| ELN238Ra01 | ELISA Kit for Notch Homolog 4 (NOTCH4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN238Ca01 | Recombinant Notch Homolog 4 (NOTCH4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN238Ca01 | Monoclonal Antibody to Notch Homolog 4 (NOTCH4) | WB; IHC; ICC; IP. |
| PAN238Ca01 | Polyclonal Antibody to Notch Homolog 4 (NOTCH4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN238Ca01 | CLIA Kit for Notch Homolog 4 (NOTCH4) | CLIA assay for Antigen Detection |
| ELN238Ca01 | ELISA Kit for Notch Homolog 4 (NOTCH4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN238Po01 | Recombinant Notch Homolog 4 (NOTCH4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN238Po01 | Monoclonal Antibody to Notch Homolog 4 (NOTCH4) | WB; IHC; ICC; IP. |
| PAN238Po01 | Polyclonal Antibody to Notch Homolog 4 (NOTCH4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN238Po01 | CLIA Kit for Notch Homolog 4 (NOTCH4) | CLIA assay for Antigen Detection |
| ELN238Po01 | ELISA Kit for Notch Homolog 4 (NOTCH4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN238Bo01 | Recombinant Notch Homolog 4 (NOTCH4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN238Bo01 | Monoclonal Antibody to Notch Homolog 4 (NOTCH4) | WB; IHC; ICC; IP. |
| PAN238Bo01 | Polyclonal Antibody to Notch Homolog 4 (NOTCH4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN238Bo01 | CLIA Kit for Notch Homolog 4 (NOTCH4) | CLIA assay for Antigen Detection |
| ELN238Bo01 | ELISA Kit for Notch Homolog 4 (NOTCH4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN238Rb01 | Recombinant Notch Homolog 4 (NOTCH4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN238Rb01 | Monoclonal Antibody to Notch Homolog 4 (NOTCH4) | WB; IHC; ICC; IP. |
| PAN238Rb01 | Polyclonal Antibody to Notch Homolog 4 (NOTCH4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN238Rb01 | CLIA Kit for Notch Homolog 4 (NOTCH4) | CLIA assay for Antigen Detection |
| ELN238Rb01 | ELISA Kit for Notch Homolog 4 (NOTCH4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN238Mo01 | Recombinant Notch Homolog 4 (NOTCH4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN238Mo01 | Monoclonal Antibody to Notch Homolog 4 (NOTCH4) | WB; IHC; ICC; IP. |
| PAN238Mo01 | Polyclonal Antibody to Notch Homolog 4 (NOTCH4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN238Mo01 | CLIA Kit for Notch Homolog 4 (NOTCH4) | CLIA assay for Antigen Detection |
| ELN238Mo01 | ELISA Kit for Notch Homolog 4 (NOTCH4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Gene organization of human NOTCH4 and (CTG)n polymorphism in this human counterpart gene of mouse proto-oncogene Int3."
Gene 189:235-244(1997) [PubMed] [Europe PMC] [Abstract]
"Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene."
Genomics 51:45-58(1998) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
"Human ligands of the Notch receptor."
Am. J. Pathol. 154:785-794(1999) [PubMed] [Europe PMC] [Abstract]
"MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors."
Nat. Genet. 26:484-489(2000) [PubMed] [Europe PMC] [Abstract]
"Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors."
Mol. Cell. Biol. 22:7688-7700(2002) [PubMed] [Europe PMC] [Abstract]