Bcl2 Related Protein A1 (BCL2A1)

ACC-1; ACC-2; BCL2L5; BFL1; GRS; HBPA1; Bcl-2-like protein 5; Hemopoietic-specific early response protein

SPN	N137
HGNC	991
MGI	102687
PubMed	23447565
UniProt	Q16548
Wiki	BCL2A1

BCL2A1encodes a member of the bcl2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.

Reference

"A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow."
Oncogene 11:1693-1698(1995) [PubMed] [Europe PMC] [Abstract]

"Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells."
Blood 87:3089-3096(1996) [PubMed] [Europe PMC] [Abstract]

"GRS, a novel member of the Bcl-2 gene family, is highly expressed in multiple cancer cell lines and in normal leukocytes."
Oncogene 14:997-1001(1997) [PubMed] [Europe PMC] [Abstract]

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of Bax-sigma, a cell death-inducing isoform of Bax."
Biochem. Biophys. Res. Commun. 270:868-879(2000) [PubMed] [Europe PMC] [Abstract]

"Human Bop is a novel BH3-only member of the Bcl-2 protein family."
Protein Cell 3:790-801(2012) [PubMed] [Europe PMC] [Abstract]

"Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim."
FEBS Lett. 582:3590-3594(2008) [PubMed] [Europe PMC] [Abstract]

"Human BCL-2A1 in complex with BIM."
Submitted (FEB-2008) to the PDB data bank

"Crystal structure of human bfl-1 in complex with noxa bh3 peptide."
Submitted (JUL-2010) to the PDB data bank