Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2)

CAMKK; CAMKKB; Calcium/calmodulin-dependent protein kinase kinase beta

SPN	N107
HGNC	1470
MGI	2444812
PubMed	23583109
RGD	620092
UniProt	Q96RR4
Wiki	CAMKK2

CAMKK2belongs to the serine/threonine-specific protein kinase family, and to the Ca⁺⁺/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4.

CaMKK2 regulates production of the appetite stimulating hormone neuropeptide Y and functions as an AMPK kinase in the hypothalamus. It also has an important role in the development of hyperalgesia and tolerance to opioid analgesic drugs, through reduction in downstream signalling pathways and mu opioid receptor downregulation. Inhibition of CaMKK2 in mice reduces appetite and promotes weight loss.

Reference

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