CD5 Antigen Like Protein (CD5L)

API6; CT-2; SP-ALPHA; Spalpha; Apoptosis Inhibitor 6; Scavenger Receptor Cysteine Rich Family; IgM-associated peptide

SPN	N088
HGNC	1690
MGI	1334419
PubMed	21697282
RGD	1308526
UniProt	O43866
Wiki	CD5L

Scavenger receptor cysteine-rich (SRCR) family members are among the proteins that regulate leukocyte function. One group of SRCR proteins includes CD5 and CD6, both of which have 3 SRCR-like domains each containing 8 cysteine residues in their extracellular region, a hydrophobic transmembrane domain, and a long cytoplasmic domain.

The predicted 347-amino acid protein, which they called Sp-alpha, has a 19-amino acid signal sequence followed by 3 cysteine-rich SRCR domains. Northern blot analysis detected 3 mRNAs of 2.4, 2.1, and 1.8 kb in spleen, lymph node, thymus, bone marrow, and fetal liver, but not in nonlymphoid tissues. Some resting myeloid cell lines, as well as peripheral blood monocytes, were capable of binding Sp-alpha.

Reference

"Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins."
J. Biol. Chem. 272:6151-6158(1997) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Two-dimensional polyacrylamide gel electrophoresis analysis of cryoglobulins and identification of an IgM-associated peptide."
J. Immunol. Methods 173:63-75(1994) [PubMed] [Europe PMC] [Abstract]

"IgM are associated to Spalpha (CD5 antigen-like)."
Electrophoresis 23:1203-1206(2002) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]