Endoplasmic Reticulum Lipid Raft Associated Protein 2 (ERLIN2)

Erlin-2; SPFH2; NET32; C8orf2; ER Lipid Raft Associated Protein 2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2

SPN	M879
HGNC	1356
MGI	2387215
PubMed	22681620
RGD	1309010
UniProt	O94905
Wiki	ERLIN2

SPFH2 associated rapidly with activated IP3 receptors , which are substrates for the ERAD pathway, in various mammalian cell lines. A proportion of SPFH2 associated with several components of the ERAD pathway, and RNA interference-mediated depletion of SPFH2 inhibited polyubiquitination and degradation of IP3R1 and turnover of model ERAD substrates. The deduced 339- and 152-amino acid proteins share the first 141 N-terminal amino acids, then diverge. Both proteins have an N-glycosylation site and type-2 membrane topology, and the longer protein has a lysine- and glutamic acid-rich region. Northern blot analysis detected ubiquitous expression of 1.6- and 2.5-kb transcripts; a minor 4.4-kb transcript was also observed.

Reference

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