Family With Sequence Similarity 3, Member B (FAM3B)

ORF9; PANDER; PRED44; C21orf11; C21orf76; Cytokine-like protein 2-21; Pancreatic-derived factor

SPN	M876
HGNC	1253
MGI	1270150
PubMed	23059759
RGD	1311662
UniProt	P58499
Wiki	FAM3B

The authors predicted that FAM3B forms a 4-helix bundle, and 3-dimensional modeling indicated that 4 cysteines could form 2 disulfide bonds linking helices 1 and 4 and helices 2 and 3. The human and mouse FAM3B proteins share 78% amino acid identity. Northern blot analysis detected FAM3B expression at a high level in pancreas and at lower levels in small intestine and prostate. Immunohistochemical analysis of mouse tissues detected prominent Fam3b staining in the endocrine pancreas, specifically in the islets of Langerhans. Staining was also found in round spermatids within the seminiferous tubules, in the Purkinje cell layer of the cerebellum, and in nerve cell bodies of numerous brainstem nuclei. Transfected Chinese hamster ovary cells secreted Fam3b to the culture medium.

Reference

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Genomics 78:46-54(2001) [PubMed] [Europe PMC] [Abstract]

"Cloning, expression, and initial characterization of a novel cytokine-like gene family."
Genomics 80:144-150(2002) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structure-function studies of PANDER, an islet specific cytokine inducing cell death of insulin-secreting beta cells."
Biochemistry 44:11342-11352(2005) [PubMed] [Europe PMC] [Abstract]