GADD45a is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms.
GADD45 is the only known x-ray responsive gene whose induction is not mediated by PKC. Sequence analysis of human and hamster cDNA clones demonstrated that the gene has been highly conserved and encodes a novel 165-amino acid polypeptide that is 96% identical in the 2 species.
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
CLIA assay for Antigen Detection
Reference
"Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C." Mol. Cell. Biol. 11:1009-1016(1991) [PubMed] [Europe PMC] [Abstract]
"Analysis of the mammalian gadd45 gene and its response to DNA damage." J. Biol. Chem. 268:24385-24393(1993) [PubMed] [Europe PMC] [Abstract]