Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b)
GADD45BETA; MYD118; Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118
GADD45b is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs.
Gadd45b is required for activity-induced DNA demethylation of specific promoters and expression of corresponding genes necessary for adult neurogenesis, including brain-derived neurotrophic factor and fibroblast growth factor. Hence GADD45B is implicated in affecting synaptic plasticity.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM850Hu01 | Recombinant Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM850Hu01 | Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | WB; IHC; ICC; IP. |
| PAM850Hu01 | Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM850Hu01 | CLIA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | CLIA assay for Antigen Detection |
| ELM850Hu01 | ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM850Mu01 | Recombinant Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM850Mu01 | Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | WB; IHC; ICC; IP. |
| PAM850Mu01 | Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM850Mu01 | CLIA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | CLIA assay for Antigen Detection |
| ELM850Mu01 | ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM850Ra01 | Recombinant Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM850Ra01 | Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | WB; IHC; ICC; IP. |
| PAM850Ra01 | Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM850Ra01 | CLIA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | CLIA assay for Antigen Detection |
| ELM850Ra01 | ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM850Ca01 | Recombinant Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM850Ca01 | Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | WB; IHC; ICC; IP. |
| PAM850Ca01 | Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM850Ca01 | CLIA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | CLIA assay for Antigen Detection |
| ELM850Ca01 | ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM850Po01 | Recombinant Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM850Po01 | Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | WB; IHC; ICC; IP. |
| PAM850Po01 | Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM850Po01 | CLIA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | CLIA assay for Antigen Detection |
| ELM850Po01 | ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM850Bo01 | Recombinant Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM850Bo01 | Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | WB; IHC; ICC; IP. |
| PAM850Bo01 | Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM850Bo01 | CLIA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | CLIA assay for Antigen Detection |
| ELM850Bo01 | ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM850Rb01 | Recombinant Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM850Rb01 | Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | WB; IHC; ICC; IP. |
| PAM850Rb01 | Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM850Rb01 | CLIA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | CLIA assay for Antigen Detection |
| ELM850Rb01 | ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM850Mo01 | Recombinant Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM850Mo01 | Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | WB; IHC; ICC; IP. |
| PAM850Mo01 | Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM850Mo01 | CLIA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | CLIA assay for Antigen Detection |
| ELM850Mo01 | ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK."
Cell 95:521-530(1998) [PubMed] [Europe PMC] [Abstract]
"Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation hybrid mapping."
Cytogenet. Cell Genet. 88:95-96(2000) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle."
J. Biol. Chem. 278:28079-28088(2003) [PubMed] [Europe PMC] [Abstract]