Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 1 (GFRa1)

GDNFR; GDNFRA; GFR-ALPHA-1; RET1L; RETL1; TRNR1; GDNF family receptor alpha-1; TGF-beta-related neurotrophic factor receptor 1

SPN	M837
HGNC	4243
MGI	1100842
PubMed	22056784
RGD	2681
UniProt	P56159

GFRA1 is released by neuronal cells, Schwann cells, and injured sciatic nerve. RET stimulation in trans by soluble or immobilized GFRA1 potentiates downstream signaling, neurite outgrowth, and neuronal survival, and elicits dramatic localized expansions of axons and growth cones.

Soluble GFRA1 mediates robust recruitment of RET to lipid rafts via a mechanism requiring the RET tyrosine kinase. Activated RET associates with different adaptor proteins inside and outside lipid rafts. The authors concluded that these results provide an explanation of the tissue distribution of GFRA1, supporting the physiologic importance of RET activation in trans as a mechanism to potentiate and diversify the biologic responses to GDNF.

Reference

"GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF."
Cell 85:1113-1124(1996) [PubMed] [Europe PMC] [Abstract]

"Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins."
Proc. Natl. Acad. Sci. U.S.A. 94:6238-6243(1997) [PubMed] [Europe PMC] [Abstract]

"Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility."
Genomics 48:354-362(1998) [PubMed] [Europe PMC] [Abstract]

"Mutational analysis of the GDNF/RET-GDNFR-alpha signaling complex in a kindred with vesicoureteral reflux."
Hum. Genet. 102:474-478(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"An unappreciated role for RNA surveillance."
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular analysis of congenital central hypoventilation syndrome."
Hum. Genet. 114:22-26(2003) [PubMed] [Europe PMC] [Abstract]