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Granzyme H (GZMH)
Granzyme H (GZMH)
CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2; Cathepsin G-Like 2,Protein h-CCPX; Cytotoxic T-lymphocyte proteinase; Cytotoxic serine protease C
GZMH is located in a cluster on 14q11.2 with cathepsin G and CTSGL1. A similar cluster of genes in the mouse is located on chromosome 14 near the TCRA locus.
Granzymes are serine proteases that are released by cytoplasmic granules within cytotoxic T cells and natural killer cells. Their purpose is to induce apoptosis within virus-infected cells, thus destroying them.Cytotoxic T cells and natural killer cells release a protein called perforin, which attacks the target cells. Researchers used to think that perforin creates pores within the cells, through which the granzymes can enter, inducing apoptosis. However, new evidence indicates that GrB complex can enter a cell through the mannose 6-phosphate receptor and is enclosed in a vesicle.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
M812Hu01
Recombinant Granzyme H (GZMH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Granzyme H (GZMH) Bioactivity
Antibodies
MM812Hu21
Monoclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IP.
PM812Hu01
Polyclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Granzyme H (GZMH) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Granzyme H (GZMH) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Granzyme H (GZMH) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry;ICC/IF
Assay Kits
KEM812Hu
ELISA Kit for Granzyme H (GZMH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Granzyme H (GZMH) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Granzyme H (GZMH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Granzyme H (GZMH) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Granzyme H (GZMH) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Granzyme H (GZMH) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Granzyme H (GZMH) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Granzyme H (GZMH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Granzyme H (GZMH) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Granzyme H (GZMH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Granzyme H (GZMH) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Granzyme H (GZMH) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Granzyme H (GZMH) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Granzyme H (GZMH) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Granzyme H (GZMH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Granzyme H (GZMH) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Granzyme H (GZMH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Granzyme H (GZMH) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Granzyme H (GZMH) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Granzyme H (GZMH) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Granzyme H (GZMH) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Granzyme H (GZMH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Granzyme H (GZMH) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Granzyme H (GZMH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Granzyme H (GZMH) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Granzyme H (GZMH) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Granzyme H (GZMH) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Granzyme H (GZMH) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Granzyme H (GZMH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Granzyme H (GZMH) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Granzyme H (GZMH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Granzyme H (GZMH) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Granzyme H (GZMH) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Granzyme H (GZMH) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Granzyme H (GZMH) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Granzyme H (GZMH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Granzyme H (GZMH) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Granzyme H (GZMH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Granzyme H (GZMH) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Granzyme H (GZMH) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Granzyme H (GZMH) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Granzyme H (GZMH) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Granzyme H (GZMH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Granzyme H (GZMH) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Granzyme H (GZMH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Granzyme H (GZMH) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Granzyme H (GZMH) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Granzyme H (GZMH) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Granzyme H (GZMH) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Granzyme H (GZMH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Granzyme H (GZMH) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Granzyme H (GZMH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Granzyme H (GZMH) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Granzyme H (GZMH) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Granzyme H (GZMH) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Granzyme H (GZMH) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Granzyme H (GZMH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Granzyme H (GZMH) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Granzyme H (GZMH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Granzyme H (GZMH) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Granzyme H (GZMH) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Granzyme H (GZMH) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Granzyme H (GZMH) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Granzyme H (GZMH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Granzyme H (GZMH) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Granzyme H (GZMH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Granzyme H (GZMH) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Granzyme H (GZMH) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Granzyme H (GZMH) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Granzyme H (GZMH) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Granzyme H (GZMH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Granzyme H (GZMH) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Granzyme H (GZMH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Granzyme H (GZMH) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Granzyme H (GZMH) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Granzyme H (GZMH) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Granzyme H (GZMH) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Granzyme H (GZMH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Granzyme H (GZMH) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Granzyme H (GZMH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Granzyme H (GZMH) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Granzyme H (GZMH) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Granzyme H (GZMH) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Granzyme H (GZMH) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Granzyme H (GZMH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Granzyme H (GZMH) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Granzyme H (GZMH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Granzyme H (GZMH) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Granzyme H (GZMH) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Granzyme H (GZMH) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Granzyme H (GZMH) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Granzyme H (GZMH) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Granzyme H (GZMH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Granzyme H (GZMH) CLIA assay for Antigen Detection
Reference
"Cloning of a gene that encodes a new member of the human cytotoxic cell protease family." Biochemistry 29:4042-4049(1990) [PubMed ] [Europe PMC ] [Abstract ]
"Structure and evolutionary origin of the human granzyme H gene." Int. Immunol. 3:57-66(1991) [PubMed ] [Europe PMC ] [Abstract ]
"Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C)." Tissue Antigens 35:220-228(1990) [PubMed ] [Europe PMC ] [Abstract ]
"The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed ] [Europe PMC ] [Abstract ]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14:2121-2127(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif." J. Immunol. 188:765-773(2012) [PubMed ] [Europe PMC ] [Abstract ]
"Identification of SERPINB1 as a physiological inhibitor of human granzyme H." J. Immunol. 190:1319-1330(2013) [PubMed ] [Europe PMC ] [Abstract ]
