High Temperature Requirement Factor A1 (HTRA1)

HtrA; L56; ORF480; PRSS11; HtrA Serine Peptidase 1; Protease,Serine,11; IGFBP5-Protease; High-temperature requirement A serine peptidase 1

SPN	M783
HGNC	9476
MGI	1929076
PubMed	16377621
RGD	69235
UniProt	Q92743
Wiki	HTRA1

HTRA1 encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth.The deduced 480-amino acid protein is 98% identical to the cow, guinea pig, and rabbit proteins. It contains an N terminus homologous to MAC25 (IGFBP7) with a conserved Kazal-type serine protease inhibitor motif, as well as a C-terminal PDZ domain. Semiquantitative RT-PCR and immunoblot analyses showed an approximately 7-fold increase of PRSS11 in osteoarthritis cartilage compared with controls. Functional and mutational analyses indicated that PRS11 is a serine protease dependent on the presence of a serine at position 328.

Reference

"Primary structure of a putative serine protease specific for IGF-binding proteins."
FEBS Lett. 398:187-192(1996) [PubMed] [Europe PMC] [Abstract]

"Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage."
J. Biol. Chem. 273:34406-34412(1998) [PubMed] [Europe PMC] [Abstract]

"The serine protease HtrA1 is upregulated in the human placenta during pregnancy."
J. Histochem. Cytochem. 52:885-892(2004) [PubMed] [Europe PMC] [Abstract]

"The role of human HtrA1 in arthritic disease."
J. Biol. Chem. 281:6124-6129(2006) [PubMed] [Europe PMC] [Abstract]

"HTRA1 promoter polymorphism in wet age-related macular degeneration."
Science 314:989-992(2006) [PubMed] [Europe PMC] [Abstract]

"A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration."
Science 314:992-993(2006) [PubMed] [Europe PMC] [Abstract]

"The serine protease HtrA1 specifically interacts and degrades the tuberous sclerosis complex 2 protein."
Mol. Cancer Res. 8:1248-1260(2010) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the PDZ-domain of human protease HTRA 1 precursor."
Submitted (APR-2008) to the PDB data bank

"Substrate-induced remodeling of the active site regulates human HTRA1 activity."
Nat. Struct. Mol. Biol. 18:386-388(2011) [PubMed] [Europe PMC] [Abstract]

"Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease."
N. Engl. J. Med. 360:1729-1739(2009) [PubMed] [Europe PMC] [Abstract]