Interleukin 1 Family, Member 9 (IL1F9)

IL-1F9; IL36g; IL-1H1; IL-1RP2; IL1E; IL1H1; IL1RP2; Interleukin 36, Gamma; Interleukin-1 Homolog 1; Interleukin-1 epsilon; Interleukin 1-Related Protein 2

SPN	M766
HGNC	15741
MGI	2449929
PubMed	23388002
RGD	1563019
UniProt	Q9NZH8
Wiki	IL1F9

IL1F9 encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2, and is specifically inhibited by interleukin 1 family, member 5 . Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up-regulated in lesional psoriasis skin.

Reference

"Identification and initial characterization of four novel members of the interleukin-1 family."
J. Biol. Chem. 275:10308-10314(2000) [PubMed] [Europe PMC] [Abstract]

"Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2."
J. Immunol. 167:1440-1446(2001) [PubMed] [Europe PMC] [Abstract]

"Identification and gene organization of three novel members of the IL-1 family on human chromosome 2."
Genomics 66:213-216(2000) [PubMed] [Europe PMC] [Abstract]

"A sequence-based map of the nine genes of the human interleukin-1 cluster."
Genomics 79:718-725(2002) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Regulation and function of the IL-1 family cytokine IL-1F9 in human bronchial epithelial cells."
Am. J. Respir. Cell Mol. Biol. 45:145-153(2011) [PubMed] [Europe PMC] [Abstract]

"Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity."
J. Biol. Chem. 286:42594-42602(2011) [PubMed] [Europe PMC] [Abstract]

"IL-36gamma/IL-1F9, an innate T-bet target in myeloid cells."
J. Biol. Chem. 287:41684-41696(2012) [PubMed] [Europe PMC] [Abstract]

"The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses."
Eur. J. Immunol. 43:416-426(2013) [PubMed] [Europe PMC] [Abstract]

"IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin."
J. Immunol. 192:6053-6061(2014) [PubMed] [Europe PMC] [Abstract]